BCC2304
Pralatrexate
Pralatrexate(Folotyn) is an antifolate, and structurally a folate analog.
BCN2179
Pemetrexed disodium
Pemetrexed disodium (LY231514 disodium) is a novel antifolate, the Kis of the pentaglutamate of Pemetrexed disodium (LY231514 disodium) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.
BCC2307
Pyrimethamine
Pyrimethamine(RP4753) is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).
BCC2301
Methotrexate
Methotrexate (Amethopterin) is an antimetabolite and antifolate agent that inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate (Amethopterin) is the disease-modifying antirheumatic drug (DMARD) of first choice for the treatment of RA in most countries worldwide. Methotrexate is an antineoplastic agent used to fight a number of different cancers, such as acute lymphoblastic leukemia and solid cancers.
