P450

Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

Products for P450

  1. Cat.No. Product Name Information
  2. BCN2184 Abiraterone Acotate
  3. BCN3479 Alizarin
  4. BCC2259 AbirateronePotent CYP17 inhibitor
  5. BCC2270 PF-4981517Selective CYP3A4 inhibitor
  6. BCC2272 KetoconazoleCytochrome P450c17 inhibitor
  7. BCC2274 AvasimibeACAT inhibitor,orally bioavailable
  8. BCC4249 (+)-Ketoconazole

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