P450
Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.
Products for P450
- Cat.No. Product Name Information
- BCN2184 Abiraterone Acotate
- BCN3479 Alizarin
- BCC2259 AbirateronePotent CYP17 inhibitor
- BCC2270 PF-4981517Selective CYP3A4 inhibitor
- BCC2272 KetoconazoleCytochrome P450c17 inhibitor
- BCC2274 AvasimibeACAT inhibitor,orally bioavailable
- BCC4249 (+)-Ketoconazole