E3 Ligase
E3 ligases perform the last step in the ubiquitination cascade. They transfer the ubiquitin from the active site cysteine of E2 enzyme to the substrate lysine or N terminus. The loss of function or mis-targeting of the E3 ligases are associated with various cancer types.
Products for E3 Ligase
- Cat.No. Product Name Information
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BCC4200
CC0651Allosteric inhibitor of hCdc34
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BCC6152
SMER 3Selective inhibitor of E3 ubiquitin ligase
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BCC6354
PRT 4165Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
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BCC7988
NSC 624206Ubiquitin-activating enzyme (E1) inhibitor
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BCC8004
SZL P1-41Selective Skp2 inhibitor; suppresses E3 ligase activity
