Products with Activators bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2823 | Dimethyl lithospermate B |
| Dimethyl lithospermate B is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action.Dimethyl lithospermate B slows inactivation of INa, leading to increased inward current during the early phases of the action potential (AP), might be an excellent candidate for a Na(+) channel agonist; it is effective in eliminating the arrhythmogenic substrate responsible for the Brugada syndrome and that it deserves further study as a pharmacological adjunct to implanted cardioverter/defibrillator usage. | |
| BCN2918 | Pratensein |
| 1. Pratensein has robust activation of acetylcholinesterase expression, the induction of acetylcholinesterase included the levels of mRNA, protein and enzymatic activity. 2. Pratensein can significantly ameliorate Aβ1-42-induced spatial learning and memory impairment through reducing neuroinflammation via inhibition of glial activation and NF-κB activation, and restoring synapse and BDNF levels, suggests that administration of pratensein could likely provide a therapeutic approach for AD. 3. Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells. 4. Pratensein can protect dopaminergic neurons against LPS-induced injury through inhibition of microglia activation and proinflammatory factors generation. | |
| BCN3830 | Incensole acetate |
| Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation. Incensole acetate has protective effects on cerebral ischemic injury, it can reduce depressive-like behavior and modulate hippocampal BDNF and CRF expression of submissive animals. | |
| BCN3995 | p-Hydroxyphenethyl trans-ferulate |
| 1. P-Hydroxyphenethyl trans-ferulate exhibits affinity toward 5-HT(7) receptors in a competitive binding assay. 2. P-Hydroxyphenethyl trans-ferulate can double quinone reductase specific activity in Hepa 1c1c7 cells at a level of 2.1 microg/mL (6.6 microM). | |
| BCN4303 | Obacunone |
| Obacunone is a novel activator of Nrf2, which exhibits anti-cancer, anti-inflammatory, antivirulence, insecticidal, anti-proliferative and anti-aromatase activities. Obacunone stimulates muscle hypertrophy and prevents obesity and hyperglycemia, and that these beneficial effects are likely to be mediated through the activation of TGR5 and inhibition of PPARγ transcriptional activity. Obacunone significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM, and it also inhibits the p38 MAPK signaling pathway. | |
