Products with Anti-Atherosclerotic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2728 | Abietic acid |
| Abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.Abietic acid acts as a PPARα/γ dual activator to inhibit UVB-induced MMP-1 expression and age-related inflammation by suppressing NF-κB and the MAPK/AP-1 pathway and can be a useful agent for improving skin photoageing. Abietic acid can be used not only for anti-inflammation but also for regulating lipid metabolism and atherosclerosis. | |
| BCN2751 | 7Beta-Hydroxycholesterol |
| 7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells. 7beta-Hydroxycholesterol and 7-ketocholesterol have dual cytotoxic effects on the cells of the vascular wall by their ability to induce apoptosis in endothelial and smooth muscle cells and necrosis in fibroblasts. 7beta-Hydroxycholesterol can inhibit the proliferation of NCI-H460 cells through apoptosis via caspase activation. It can reinforce the susceptibility of K562 adriamycin-resistant cells to this drug, it also can enhance radiosensitivity in RDM4 cells. | |
| BCN2773 | Tomatidine |
| Tomatidine shows antibiotic, and anti-inflammatory activities, it significantly suppresses the activity of ACAT and leads to reduction of atherogenesis. Tomatidine inhibits the invasion of A549 cells by reducing the expression of MMPs, also inhibits ERK and Akt signaling pathways and NF-κB activity, suggests a new therapeutic potential for Tomatidine in anti-metastatic therapy. | |
| BCN2897 | Soyasaponin Ac |
| 1. Soyasaponins have chemoprevention activities, they prevent H2O₂-induced inhibition of gap junctional intercellular communication by scavenging reactive oxygen species in rat liver cells. 2. Soyasaponins can significantly decrease blood glucose, improve atherosclerotic index, and inhibit lipid peroxidation and platelet aggregation in diabetic rats, which may be useful in prevention and control of diabetes mellitus and diabetes-associated atherosclerosis. 3. Soyasaponins abundant in soybean have anti-inflammatory activities, low-dose SSs alleviated contact hypersensitivity (CHS) symptoms by attenuating inflammation and improving the intestinal microbiota composition, suggesting that dietary SSs may have beneficial effects on allergic contact dermatitis (ACD). 4. Dietary soyasaponin has inhibitory effects on 2,4-dinitrofluorobenzene-induced contact hypersensitivity in mice. | |
| BCN2998 | 8-Prenylnaringenin |
| 8-Prenylnaringenin is a phytoestrogen with high estrogenic activity, it shows more potent effects on promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption by ERα instead of ERβ than the two classic phytoestrogens: genistein and daidzein. 8-Prenylnaringenin at all assayed doses (0.001-20 µM) presumably improves mitochondrial function, whereas a high dose of XN (5 µM) worsens the functionality of this organelle. | |
