Products with Anti-inflammatory bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1169 | Cleroindicin F |
| 1. Cleroindicin F shows cytotoxic activity against some human cancer cells. 2. Cleroindicin F and apigenin in the ethyl acetate extract provide scientific support to the traditional use of the leaves of C. splendens for the treatment of infections, wounds and other inflammatory conditions. | |
| BCN1178 | Salvigenin |
| Salvigenin, a potent hMAO-A [monoamine oxidases (MAOs)]inhibitor, has neuroprotective, antitumor and immunomodulatory effects, it has potential to ameliorate Streptozotocin-induced diabetes mellitus and heart complications in rats. Salvigenin has dose-dependent analgesic effect so that it can be useful in controlling of inflammations, acute and chronic pain. | |
| BCN1182 | Deoxypodophyllotoxin |
| Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities. Deoxypodophyllotoxin induces G2 /M cell-cycle arrest followed by apoptosis through multiple cellular processes, involving the activation of ATM, upregulation of p53 and Bax, activation of caspase-3 and -7, and accumulation of PTEN resulting in the inhibition of the Akt pathway. Deoxypodophyllotoxin maybe applicable to treat hyperpigmentation, it decreases UV-induced skin pigmentation of brown guinea pigs. | |
| BCN1184 | Cardamonin |
| Cardamonin is a naturally occurring chalcone with strong anti-inflammatory , anticancer, anti-melanogenesis, and vascular activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor. It ameliorates insulin resistance induced by high insulin and high glucose through the mTOR and signal pathway. It also may be a potential whitening agent for use in cosmetics and in the medical treatment of hyperpigmentation disorders. | |
| BCN1189 | Alphitolic acid |
| 1. Alphitolic acid is an anti-inflammatory triterpene, has antitumour activity in oral squamous cell carcinoma (OSCC) cells. 2. Alphitolic acid can suppress the proliferation of SCC4 and SCC2095 OSCC cells with IC50 values of 12 and 15 uM, respectively, via apoptotic induction, this drug effect on apoptosis is, in part, associated with its ability to block Akt-NF-κB signalling; it could as an ingredient in functional food/dietary supplement for OSCC prevention. 3. Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotoxicity against cancer cells. 4. Alphitolic acid shows antimicrobial activity on Gram-positive bacteria and yeasts. 5. Alphitolic acid can inhibit NO release and iNOS expression in LPS-stimulated J774.A1 cultured macrophages. | |
