Cleroindicin FCAS# 189264-47-9 |
- (±)-Cleroindicin F
Catalog No.:BCN0466
CAS No.:94535-01-0
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 189264-47-9 | SDF | Download SDF |
| PubChem ID | 10374646 | Appearance | Oil |
| Formula | C8H10O3 | M.Wt | 154.2 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3aR,7aR)-3a-hydroxy-2,3,7,7a-tetrahydro-1-benzofuran-6-one | ||
| SMILES | C1COC2C1(C=CC(=O)C2)O | ||
| Standard InChIKey | HSGPAWIMHOPPDA-SFYZADRCSA-N | ||
| Standard InChI | InChI=1S/C8H10O3/c9-6-1-2-8(10)3-4-11-7(8)5-6/h1-2,7,10H,3-5H2/t7-,8+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Cleroindicin F shows cytotoxic activity against some human cancer cells. 2. Cleroindicin F and apigenin in the ethyl acetate extract provide scientific support to the traditional use of the leaves of C. splendens for the treatment of infections, wounds and other inflammatory conditions. |
| Targets | Antifection |
Cleroindicin F Dilution Calculator
Cleroindicin F Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.4851 mL | 32.4254 mL | 64.8508 mL | 129.7017 mL | 162.1271 mL |
| 5 mM | 1.297 mL | 6.4851 mL | 12.9702 mL | 25.9403 mL | 32.4254 mL |
| 10 mM | 0.6485 mL | 3.2425 mL | 6.4851 mL | 12.9702 mL | 16.2127 mL |
| 50 mM | 0.1297 mL | 0.6485 mL | 1.297 mL | 2.594 mL | 3.2425 mL |
| 100 mM | 0.0649 mL | 0.3243 mL | 0.6485 mL | 1.297 mL | 1.6213 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Enantioselective total synthesis of all of the known chiral cleroindicins (C-F): clarification among optical rotations and assignments.[Pubmed:19476394]
J Org Chem. 2009 Jun 5;74(11):4104-9.
Enantioselective syntheses of all of the named chiral members of the Cleroindicin Family (C-F) are reported. This effort demonstrates the synthetic utility of a 2,4-dihydroxybenzaldehyde as a starting material for natural product synthesis through the use sequential o-quinone methide chemistry and diastereoselective dearomatization. Natural Cleroindicin F was shown to be nearly racemic, and an optically pure synthetic sample of Cleroindicin F was found to racemize under slightly basic conditions. All other natural chiral cleroindicins are shown to be partially racemic.
Tandem sequence of phenol oxidation and intramolecular addition as a method in building heterocycles.[Pubmed:23110614]
J Org Chem. 2012 Nov 16;77(22):10294-303.
A tandem phenol oxidation-Michael addition furnishing oxo- and -aza-heterocycles has been developed. Dirhodium caprolactamate [Rh(2)(cap)(4)] catalyzed oxidation by T-HYDRO of phenols with alcohols, ketones, amides, carboxylic acids, and N-Boc protected amines tethered to their 4-position afforded 4-(tert-butylperoxy)cyclohexa-2,5-dienones that undergo Bronsted acid catalyzed intramolecular Michael addition in one-pot to produce oxo- and -aza-heterocycles in moderate to good yields. The scope of the developed methodology includes dipeptides Boc-Tyr-Gly-OEt and Boc-Tyr-Phe-Me and provides a pathway for understanding the possible transformations arising from oxidative stress of tyrosine residues. A novel method of selective cleavage of O-O bond in hindered internal peroxide using TiCl(4) has been discovered in efforts directed to the construction of Cleroindicin F, whose synthesis was completed in 50% yield over just 3 steps from tyrosol using the developed methodology.
