Isotanshinone IIBCAS# 109664-01-9 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 109664-01-9 | SDF | Download SDF |
| PubChem ID | 184102 | Appearance | Red powder |
| Formula | C19H18O4 | M.Wt | 310.35 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4-(hydroxymethyl)-4,8-dimethyl-2,3-dihydro-1H-naphtho[2,1-f][1]benzofuran-7,11-dione | ||
| SMILES | CC1=COC2=C1C(=O)C3=C(C2=O)C4=C(C=C3)C(CCC4)(C)CO | ||
| Standard InChIKey | VIDDDTBBUDIKKK-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C19H18O4/c1-10-8-23-18-14(10)16(21)12-5-6-13-11(15(12)17(18)22)4-3-7-19(13,2)9-20/h5-6,8,20H,3-4,7,9H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Salvia miltiorrhiza Bge.
| Description | 1. Tanshinol protects against hydrogen peroxide-induced oxidative stress via regulating Wnt/FoxO pathway in osteoblastic differentiation of C2C12 cells. 2. Tanshinol protects hippocampus and attenuates vascular dementia development, it may be a potential compound in vascular dementia (VD) model. 3. Tanshinol protects against atherosclerosis by preventing H2O2-induced apoptosis of human umbilical vein endothelial cells (HUVECs), these effects appear to be mediated by enhancing the antioxidant defenses and preserving the mitochondrial function of the cells. 4. Tanshinol can stimulate bone formation and attenuate dexamethasone-induced inhibition of osteogenesis in larval zebrafish. 5. Tanshinol attenuates oxidative stress via down-regulation of FoxO3a signaling, and rescues the decrease of osteoblastic differentiation through upregulation of Wnt signal under oxidative stress. |
| Targets | Wnt/β-catenin |
Isotanshinone IIB Dilution Calculator
Isotanshinone IIB Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.2222 mL | 16.1108 mL | 32.2217 mL | 64.4434 mL | 80.5542 mL |
| 5 mM | 0.6444 mL | 3.2222 mL | 6.4443 mL | 12.8887 mL | 16.1108 mL |
| 10 mM | 0.3222 mL | 1.6111 mL | 3.2222 mL | 6.4443 mL | 8.0554 mL |
| 50 mM | 0.0644 mL | 0.3222 mL | 0.6444 mL | 1.2889 mL | 1.6111 mL |
| 100 mM | 0.0322 mL | 0.1611 mL | 0.3222 mL | 0.6444 mL | 0.8055 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Isolation and bioactivity of new tanshinones.[Pubmed:3655791]
J Nat Prod. 1987 Mar-Apr;50(2):157-60.
Two new diterpenoids, designated neocryptotanshinone and Isotanshinone IIB, have been isolated from "Tan-Shen," the root of Salvia miltiorrhiza, together with a known compound, danshexinkun A. Their structures are established by spectral and physical data. Isotanshinone IIB exhibits significant inhibitory activity in vitro on ADP- and collagen-induced aggregation.
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