Products with Anti-inflammatory bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4390 | Eriocalyxin B |
| 1. Eriocalyxin B is a potent NF-kappaB inhibitor, can inhibit the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein. 2. Eriocalyxin B reversibly interfer with the binding of p65 and p50 subunits to the DNA in a noncompetitive manner. 3. Eriocalyxin B exerts potent antiinflammatory effects through selective modulation of pathogenic Th1 and Th17 cells by targeting critical signaling pathways. 4. Eriocalyxin B inhibits proliferation and induces apoptosis through downregulation of Bcl-2 and activation of caspase-3 in human bladder cancer cells. 5. Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment. 6. Eriocalyxin B is a specific inhibitor of STAT3, it directly targets STAT3 through a covalent linkage to inhibit the phosphorylation and activation of STAT3 and induces apoptosis of STAT3-dependent tumor cells. | |
| BCN4394 | Vasicinolone |
| 1. Vasicinolone has anti-inflammatory activity. 2. Vasicinolone has antimicrobial activity. | |
| BCN4410 | alpha-Amyrin acetate |
| 1. Alpha-Amyrin acetate has anti-inflammatory activity. 2. Alpha-Amyrin acetate has antispasmodic profile and the relaxant effects. 3. Alpha-Amyrin acetate can decrease blood engorgement time and feeding rate and decline fecundity which reduce the overall survival and reproductive capacity of the malaria vector A. stephensi. 4. The oral administration of alpha-Amyrin acetate can significantly improve the diabetic condition in streptozotocin-induced diabetic rats and in diabetic db/db mice at 50 mg kg(-1) dose level. | |
| BCN4424 | Pyrogallol |
| Pyrogallol is a polyphenol compound, which has anti-fungal, anti-psoriatic, anti-inflammatory, and antiproliferative effects . Pyrogallol is a reductant that is able to generate free radicals, in particular superoxide anions; it is both a sensitizer, a carcinogenic, and an irritant in female BALB/c mice. | |
| BCN4430 | Methyl syringate |
| Methyl syringate is a specific and selective activator of hTRPA1, can regulate food intake and gastric emptying through a TRPA1-mediated pathway and, by extension, can contribute to weight suppression. Methyl syringate has a unique inhibitory activity toward aflatoxin production. Methyl syringate could be effective to suppress hypoxia-induced inflammation, it inhibits the hypoxic induction of COX-2 expression and cell invasion through TRPA1 activation. | |
