Products with Anti-insulin resistance bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2979 | Isoastragaloside I |
| Isoastragaloside I may be promising in modulating CCl4-induced lethality and most of its toxic effects. Astragaloside II and Isoastragaloside I are sufficient to ameliorate insulin resistance, they may provide the lead as a novel class of therapeutics for obesity-related diseases. | |
| BCN2986 | 2'-Methoxykurarinone |
| 2'-Methoxykurarinone has strong alpha-glucosidase inhibitory activities, with IC(50) values of 155 microM. 2'-Methoxykurarinone is a noncompetitive inhibitor of protein tyrosine phosphatase 1B, it exhibits cellular activity in the insulin signaling pathway by increasing the insulin-stimulated Akt phosphorylation level in human hepatocellular liver carcinoma HepG2 cells, suggesting its potential for new anti-insulin-resistant drug developments. 2′-Methoxykurarinone exhibits lethal activity against Trypanosoma cruzi.,the minimum lethal concentrations is 6.9 uM. | |
| BCN3817 | Glucoraphanin |
| 1. Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, induces phase-I xenobiotic metabolizing enzymes and increases free radical generation in rat liver. 2. Glucoraphanin can ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice. 3. Glucoraphanin and Glucoerucin effectively act as antagonists for the aryl hydrocarbon receptor, and this may contribute to their established chemoprevention potency. 4. Glucoraphanin has antioxidant activity, it has important effects on the reversion of fatty liver. | |
| BCN4925 | Agrimonolide |
| 1. Agrimonolide exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of JAK-STATs and p38 MAPKs signaling pathway. 2. Agrimonolide is a potential α1 adrenergic receptor antagonist . 3. Agrimonolide and desmethylagrimonolide can effectively increase insulin-mediated glycogen level in heptocytes, they may play an important role in regulating glucose metabolism in insulin-resistance HepG2 cells and could be developed as a promising natural material for diabetes prevention and treatment. | |
| BCN5236 | Pinusolide |
| 1. Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension . 2. Pinusolide has antileukemic potential, it not only decreases the proliferation activity of tumor cells at relatively low concentrations but specifically induces apoptosis at 100 microM via the mitochondrial pathway in the Burkitt lymphoma cell line BJAB. 3. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes. 4. Pinusolide can protect neuronal cells from staurosporine (STS) -induced apoptosis, probably by preventing the increase in [Ca2+]i and cellular oxidation caused by STS, and indicate that it could be used to treat neurodegenerative diseases. 5. Pinusolide shows potent inhibition of 5-LO dependent LTC4 generation, which requires both suppression of calcium influx and JNK phosphorylation. | |
