AgrimonolideCAS# 21499-24-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 21499-24-1 | SDF | Download SDF |
| PubChem ID | 161362 | Appearance | Powder |
| Formula | C18H18O5 | M.Wt | 314.3 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3S)-6,8-dihydroxy-3-[2-(4-methoxyphenyl)ethyl]-3,4-dihydroisochromen-1-one | ||
| SMILES | COC1=CC=C(C=C1)CCC2CC3=CC(=CC(=C3C(=O)O2)O)O | ||
| Standard InChIKey | TYFJTEPDESMEHE-HNNXBMFYSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Agrimonolide exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of JAK-STATs and p38 MAPKs signaling pathway. 2. Agrimonolide is a potential α1 adrenergic receptor antagonist . 3. Agrimonolide and desmethylagrimonolide can effectively increase insulin-mediated glycogen level in heptocytes, they may play an important role in regulating glucose metabolism in insulin-resistance HepG2 cells and could be developed as a promising natural material for diabetes prevention and treatment. |
| Targets | TNF-α | NO | NOS | COX | JNK | p38MAPK | JAK | STAT | NF-kB | IL Receptor | Adrenergic Receptor |
Agrimonolide Dilution Calculator
Agrimonolide Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.1817 mL | 15.9084 mL | 31.8167 mL | 63.6335 mL | 79.5418 mL |
| 5 mM | 0.6363 mL | 3.1817 mL | 6.3633 mL | 12.7267 mL | 15.9084 mL |
| 10 mM | 0.3182 mL | 1.5908 mL | 3.1817 mL | 6.3633 mL | 7.9542 mL |
| 50 mM | 0.0636 mL | 0.3182 mL | 0.6363 mL | 1.2727 mL | 1.5908 mL |
| 100 mM | 0.0318 mL | 0.1591 mL | 0.3182 mL | 0.6363 mL | 0.7954 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- H-Arg(NO2)-OH
Catalog No.:BCC2864
CAS No.:2149-70-4
- 2-Deacetyltaxachitriene A
Catalog No.:BCN7415
CAS No.:214769-96-7
- AMT hydrochloride
Catalog No.:BCC6823
CAS No.:21463-31-0
- (+)-Syringaresinol
Catalog No.:BCN7496
CAS No.:21453-69-0
- 1400W dihydrochloride
Catalog No.:BCC7057
CAS No.:214358-33-5
- 16alpha-Hydroxybauerenol
Catalog No.:BCN7724
CAS No.:214351-30-1
- Rosamultic acid
Catalog No.:BCN3516
CAS No.:214285-76-4
- Demethylsuberosin
Catalog No.:BCN6508
CAS No.:21422-04-8
- 5,7-dimethoxy-2,2-dimethylchromene
Catalog No.:BCN8030
CAS No.:21421-66-9
- N-Benzylphthalimide
Catalog No.:BCC9096
CAS No.:2142-01-0
- Picrotin
Catalog No.:BCC8233
CAS No.:21416-53-5
- 1-Decarboxy-3-oxo-ceanothic acid
Catalog No.:BCN4924
CAS No.:214150-74-0
- Bruceine D
Catalog No.:BCN2894
CAS No.:21499-66-1
- 7,3',4'-Trihydroxyflavone
Catalog No.:BCN4674
CAS No.:2150-11-0
- Protocatechuic acid methyl ester
Catalog No.:BCN3542
CAS No.:2150-43-8
- Methyl 2,6-dihydroxybenzoate
Catalog No.:BCN3563
CAS No.:2150-45-0
- BMS 493
Catalog No.:BCC7697
CAS No.:215030-90-3
- Pemoline
Catalog No.:BCC5967
CAS No.:2152-34-3
- Betamethasone Valerate
Catalog No.:BCC3736
CAS No.:2152-44-5
- BMS 753
Catalog No.:BCC6031
CAS No.:215307-86-1
- Senampeline F
Catalog No.:BCN7804
CAS No.:71075-43-9
- Mianserin HCl
Catalog No.:BCC1114
CAS No.:21535-47-7
- SU 5402
Catalog No.:BCC1970
CAS No.:215543-92-3
- Sodium Dichloroacetate
Catalog No.:BCN2951
CAS No.:2156-56-1
Preparative purification of five bioactive components from Agrimonia pilosa Ledeb by high-speed counter-current chromatography.[Pubmed:22865760]
J Sep Sci. 2012 Aug;35(15):1977-84.
High-speed counter-current chromatography (HSCCC) coupled with ultraviolet (UV) detection or evaporative light-scattering detection was successfully applied for preparative separation of five bioactive compounds from Agrimonia pilosa Ledeb. In preliminary process, D101 macroporous resin was used to separate the crude extract of the plant and four fractions (20, 40, 50, and 60% aqueous ethanol elutions) were produced. Then, these fractions were directly subjected to HSCCC purification. Five chemicals including taxifolin-3-glucoside (6.4 mg), quercetin-3-rhamnoside (13.0 mg), tiliroside (14.7 mg), Agrimonolide (21.4 mg), and tormentic acid (29.8 mg) with the purities of 94.24, 95.37, 97.42, 95.29, and 96.34% were separated from each 200 mg prepared fraction. The purities were analyzed by high-performance liquid chromatography, and the chemical structures of the products were identified by UV detection, mass spectrometry, nuclear magnetic resonance, and the standards. This paper used a simple method to separate five bioactive compounds from A. pilosa Ledeb, and it could provide a new idea for the purification of bioactive compounds from other medicinal plants.
Agrimonolide from Agrimonia pilosa suppresses inflammatory responses through down-regulation of COX-2/iNOS and inactivation of NF-kappaB in lipopolysaccharide-stimulated macrophages.[Pubmed:27288920]
Phytomedicine. 2016 Jul 15;23(8):846-55.
BACKGROUND: Agrimonolide from Agrimonia pilosa showed a strong anti-inflammatory activity, and the present study aims to reveal potential mechanisms on molecular level explaining its anti-inflammatory effect. HYPOTHESIS/PURPOSE: To investigate the mechanism of anti-inflammatory activity of Agrimonolide. STUDY DESIGN: Anti-inflammatory activity of Agrimonolide in cells was applied. METHODS: Anti-inflammatory activity of Agrimonolide isolated from Agrimonia pilosa was evaluated using lipopolysaccharide (LPS) stimulated RAW 264.7 cell models. The productions of IL-1beta, IL-6, TNF-alpha and NO were determined by ELISA and nitrite analysis, respectively. The expressions of iNOS and COX-2 were measured by western blotting and RT-PCR analysis. RESULTS: The pre-treatment with Agrimonolide significantly reduced the levels of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha), as well as attenuated the expression of iNOS and COX-2 in LPS-stimulated macrophages. Furthermore, Agrimonolide inhibited the activation of JNK and p38 MAPKs and decreased the activation of JAK-STAT and NF-kappaB in LPS-stimulated macrophages. CONCLUSION: The present study suggested that Agrimonolide exerted anti- inflammatory activity, at least in part, via suppressing LPS-induced activation of JAK-STATs and p38 MAPKs signaling pathway.
