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7,3',4'-Trihydroxyflavone

CAS# 2150-11-0

7,3',4'-Trihydroxyflavone

Catalog No. BCN4674----Order now to get a substantial discount!

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7,3',4'-Trihydroxyflavone: 5mg $426 In Stock
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Quality Control of 7,3',4'-Trihydroxyflavone

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Chemical structure

7,3',4'-Trihydroxyflavone

3D structure

Chemical Properties of 7,3',4'-Trihydroxyflavone

Cas No. 2150-11-0 SDF Download SDF
PubChem ID 5322065 Appearance Yellow powder
Formula C15H10O5 M.Wt 270.24
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-(3,4-dihydroxyphenyl)-7-hydroxychromen-4-one
SMILES C1=CC(=C(C=C1C2=CC(=O)C3=C(O2)C=C(C=C3)O)O)O
Standard InChIKey PVFGJHYLIHMCQD-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 7,3',4'-Trihydroxyflavone

The seeds of Cassia occidentalis

Biological Activity of 7,3',4'-Trihydroxyflavone

Description1. 3'4'7-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs), it inhibits osteoclastogenesis via nuclear factor of activated T cells c1 (NFATc1).
Targetsp38MAPK | NF-kB | ATPase

7,3',4'-Trihydroxyflavone Dilution Calculator

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7,3',4'-Trihydroxyflavone Molarity Calculator

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Preparing Stock Solutions of 7,3',4'-Trihydroxyflavone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.7004 mL 18.5021 mL 37.0041 mL 74.0083 mL 92.5104 mL
5 mM 0.7401 mL 3.7004 mL 7.4008 mL 14.8017 mL 18.5021 mL
10 mM 0.37 mL 1.8502 mL 3.7004 mL 7.4008 mL 9.251 mL
50 mM 0.074 mL 0.37 mL 0.7401 mL 1.4802 mL 1.8502 mL
100 mM 0.037 mL 0.185 mL 0.37 mL 0.7401 mL 0.9251 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 7,3',4'-Trihydroxyflavone

3'4'7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1.[Pubmed:26601423]

Pharmazie. 2015 Oct;70(10):661-7.

3'4'7-Trihydroxyflavone is a flavonoid from ladino clover, alfalfa, and Albizzia julibrissin. In the present study, we found that 3'4'7-trihydroxyflavone markedly inhibited the receptor activator of nuclear factor kappa B ligand (RANKL) induced osteoclastic differentiation from mouse bone marrow derived macrophages (BMMs). 3'4'7-trihydroxyflavone also reduced the mRNA expression level of osteoclastic marker genes including calcitonin receptor (CTR), Cathepsin K1 v-ATPase V0 subunit d2 (ATP6v0d2), and dendritic cell-specific transmembrane protein (DC-STAMP). In addition, 3'4'7-trihydroxyflavone decreased the bone resorption activity of osteoclasts on dentin slices. We found that 3'4'7-trihydroxyflavone inhibited RANKL-induced expression of nuclear factor of activated T cells c1 (NFATc1), a key transcription factor of osteoclast differentiation. Furthermore, 3'4'7-trihydroxyflavone attenuated RANKL-induced activation of p38 mitogen-activated protein kinase (MAPK) and expression of B lymphocyte-induced maturation protein 1 (Blimp1), a repressor of negative regulators of NFATc1. Taken together, our data suggest that 3'4'7-trihydroxyflavone inhibits osteoclastogenesis via NFATc1.

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