1-Decarboxy-3-oxo-ceanothic acidCAS# 214150-74-0 |
Quality Control & MSDS
Number of papers citing our products
![](/media/diy/images/number_cite.png)
Chemical structure
![1-Decarboxy-3-oxo-ceanothic acid](/media/images/struct/BCN4924.png)
3D structure
Cas No. | 214150-74-0 | SDF | Download SDF |
PubChem ID | 23243541 | Appearance | Powder |
Formula | C29H44O3 | M.Wt | 440.7 |
Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
SMILES | CC(=C)C1CCC2(C1C3CCC4C(C3(CC2)C)(CCC5C4(CC(=O)C5(C)C)C)C)C(=O)O | ||
Standard InChIKey | NUDCZUBEFGYVSS-RSICVRGJSA-N | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 1. 1-Decarboxy-3-oxo-ceanothic acid shows in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, the cytotoxic effect is mediated, at least in part, by the induction of apoptosis. 2. 1-Decarboxy-3-oxo-ceanothic acid shows cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 microg/mL, respectively, and an IC50 of 11.3 microg/mL against normal cell line FS-5. |
Targets | DNA/RNA Synthesis |
![](/statics/images/closeICO.png)
1-Decarboxy-3-oxo-ceanothic acid Dilution Calculator
![](/statics/images/closeICO.png)
1-Decarboxy-3-oxo-ceanothic acid Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.2691 mL | 11.3456 mL | 22.6912 mL | 45.3823 mL | 56.7279 mL |
5 mM | 0.4538 mL | 2.2691 mL | 4.5382 mL | 9.0765 mL | 11.3456 mL |
10 mM | 0.2269 mL | 1.1346 mL | 2.2691 mL | 4.5382 mL | 5.6728 mL |
50 mM | 0.0454 mL | 0.2269 mL | 0.4538 mL | 0.9076 mL | 1.1346 mL |
100 mM | 0.0227 mL | 0.1135 mL | 0.2269 mL | 0.4538 mL | 0.5673 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
![](/media/diy/images/pphome/Calcutta University.jpg)
Calcutta University
![](/media/diy/images/pphome/University of Minnesota.jpg)
University of Minnesota
![](/media/diy/images/pphome/University of Maryland School of Medicine.jpg)
University of Maryland School of Medicine
![](/media/diy/images/pphome/University of Illinois at Chicago.jpg)
University of Illinois at Chicago
![](/media/diy/images/pphome/The Ohio State University.jpg)
The Ohio State University
![](/media/diy/images/pphome/University of Zurich.jpg)
University of Zurich
![](/media/diy/images/pphome/Harvard University.jpg)
Harvard University
![](/media/diy/images/pphome/Colorado State University.jpg)
Colorado State University
![](/media/diy/images/pphome/Auburn University.jpg)
Auburn University
![](/media/diy/images/pphome/Yale University.jpg)
Yale University
![](/media/diy/images/pphome/Worcester Polytechnic Institute.jpg)
Worcester Polytechnic Institute
![](/media/diy/images/pphome/Washington State University.jpg)
Washington State University
![](/media/diy/images/pphome/Stanford University.jpg)
Stanford University
![](/media/diy/images/pphome/University of Leipzig.jpg)
University of Leipzig
![](/media/diy/images/pphome/Universidade da Beira Interior.jpg)
Universidade da Beira Interior
![](/media/diy/images/pphome/The Institute of Cancer Research.jpg)
The Institute of Cancer Research
![](/media/diy/images/pphome/Heidelberg University.jpg)
Heidelberg University
![](/media/diy/images/pphome/University of Amsterdam.jpg)
University of Amsterdam
![](/media/diy/images/pphome/University of Auckland.jpg)
University of Auckland
![TsingHua University](/media/diy/images/pphome/TsingHua University.jpg)
TsingHua University
![The University of Michigan](/media/diy/images/pphome/University of Michigan.jpg)
The University of Michigan
![Miami University](/media/diy/images/pphome/Miami University.jpg)
Miami University
![DRURY University](/media/diy/images/pphome/DRURY University.jpg)
DRURY University
![Jilin University](/media/diy/images/pphome/Jilin University.jpg)
Jilin University
![Fudan University](/media/diy/images/pphome/Fudan University.jpg)
Fudan University
![Wuhan University](/media/diy/images/pphome/Wuhan University.jpg)
Wuhan University
![Sun Yat-sen University](/media/diy/images/pphome/Sun Yat-sen University.jpg)
Sun Yat-sen University
![Universite de Paris](/media/diy/images/pphome/Universite de Paris.jpg)
Universite de Paris
![Deemed University](/media/diy/images/pphome/Deemed University.jpg)
Deemed University
![Auckland University](/media/diy/images/pphome/Auckland University.jpg)
Auckland University
![The University of Tokyo](/media/diy/images/pphome/Tokyo University.jpg)
The University of Tokyo
![Korea University](/media/diy/images/pphome/Korea University.jpg)
Korea University
- 26-Deoxycimicifugoside
Catalog No.:BCN2906
CAS No.:214146-75-5
- Glucoraphanin
Catalog No.:BCN3817
CAS No.:21414-41-5
- Magnoflorine
Catalog No.:BCN4923
CAS No.:2141-09-5
- CART (55-102) (human)
Catalog No.:BCC6007
CAS No.:214050-22-3
- Taxiphyllin
Catalog No.:BCN4922
CAS No.:21401-21-8
- Chrysin dimethylether
Catalog No.:BCN6799
CAS No.:21392-57-4
- Barbacarpan
Catalog No.:BCN4921
CAS No.:213912-46-0
- 1-Acetoxy-9,17-octadecadiene-12,14-diyne-11,16-diol
Catalog No.:BCN1493
CAS No.:213905-35-2
- Nifenazone
Catalog No.:BCC3822
CAS No.:2139-47-1
- Zedoarofuran
Catalog No.:BCN3527
CAS No.:213833-34-2
- 6,8-Cyclo-1,4-eudesmanediol
Catalog No.:BCN4920
CAS No.:213769-80-3
- 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative
Catalog No.:BCC7102
CAS No.:213766-21-3
- Picrotin
Catalog No.:BCC8233
CAS No.:21416-53-5
- N-Benzylphthalimide
Catalog No.:BCC9096
CAS No.:2142-01-0
- 5,7-dimethoxy-2,2-dimethylchromene
Catalog No.:BCN8030
CAS No.:21421-66-9
- Demethylsuberosin
Catalog No.:BCN6508
CAS No.:21422-04-8
- Rosamultic acid
Catalog No.:BCN3516
CAS No.:214285-76-4
- 16alpha-Hydroxybauerenol
Catalog No.:BCN7724
CAS No.:214351-30-1
- 1400W dihydrochloride
Catalog No.:BCC7057
CAS No.:214358-33-5
- (+)-Syringaresinol
Catalog No.:BCN7496
CAS No.:21453-69-0
- AMT hydrochloride
Catalog No.:BCC6823
CAS No.:21463-31-0
- 2-Deacetyltaxachitriene A
Catalog No.:BCN7415
CAS No.:214769-96-7
- H-Arg(NO2)-OH
Catalog No.:BCC2864
CAS No.:2149-70-4
- Agrimonolide
Catalog No.:BCN4925
CAS No.:21499-24-1
In vitro cytotoxic activity of 1-decarboxy-3-oxo-ceanothic acid in a human ovarian adenocarcinoma cell line.[Pubmed:9730010]
Res Commun Mol Pathol Pharmacol. 1998 Jun;100(3):313-26.
The effect of a novel pentacyclic triterpene, 1-Decarboxy-3-oxo-ceanothic acid (DOCA) on DNA synthesis, DNA degradation and programmed cell death was examined in human ovarian adenocarcinoma (OVCAR-3) cells. OVCAR-3 cells exposed to various concentrations of DOCA for 30 h displayed a dose-dependent inhibition of DNA synthesis. Morphologically, treatment with 10 microg/ml of DOCA for 24 h and 72 h resulted respectively in reduction in cell volume and condensation of nuclear structures. By agarose gel analysis, DNA fragmentation with the characteristic pattern of inter-nucleosomal ladder was observed after cells were treated with 2.5 microg/ml of DOCA for 24 h. Both cell death and DNA fragmentation caused by this compound were partially inhibited by the protein synthesis inhibitor cycloheximide, suggesting that the apoptotic process caused by DOCA requires synthesis of new proteins. On the other hand, no apparent double-stranded DNA breaks were detected after cells were incubated with 2.5 microg/ml of DOCA for 24 h, indicating that DNA damage was not a preceding event for apoptosis induced by this compound. Taken together, our results demonstrate that the cytotoxic effect of DOCA is mediated, at least in part, by the induction of apoptosis.
Preparation and cytotoxic effect of ceanothic acid derivatives.[Pubmed:9834149]
J Nat Prod. 1998 Nov;61(11):1343-7.
Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-Decarboxy-3-oxo-ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 microg/mL, respectively, and an IC50 of 11.3 microg/mL against normal cell line FS-5.