Products with Anti-metastatic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2318 | Gambogic acid |
| Gambogic acid is a tissue-specific proteasome inhibitor, which has anticancer, anti-inflammatory, and anti-angiogenesis activities. Gambogic acid induces LRIG1 (leucine-rich repeat and Ig-like domain-containing-1) upregulation, which is responsible for EGFR (epidermal growth factor receptor) degradation and its downstream Akt/mTORC1 inhibition. | |
| BCN2390 | Brucine |
| Brucine has anti-cncer activity, it can treat hepatocellular carcinoma (HCC) and inhibit the proliferation of human lung cancer cell line PC-9 mainly by blocking the cell cycle at G0/G1 via down-regulating the expression of Cyclin D1, Cyclin E. | |
| BCN2447 | Ganoderenic acid H |
| 1. Ganoderenic acid H is one compound of triterpenoids isolated from Ganoderma lucidum, triterpenoids exhibit a broad spectrum of anti-cancer properties, including anti-proliferative, anti-metastatic and anti-angiogenic activities. | |
| BCN2563 | 4-Methylumbelliferone |
| 4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM, which has antitumoral and antimetastatic effects. 4-Methylumbelliferone may inhibit the phosphorylation of HAS2 by PKC through the stimulation of O-GlcNAcylation; it also similarly ameliorates hypertriglyceridemia and hyperglycemia partly by modulating hepatic lipid metabolism and the antioxidant defense system along with increasing adiponectin levels. | |
| BCN3150 | Cyanidin-3-O-sambubioside chloride |
| 1. Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NFκB activity. 2. Cyanidin-3-O-sambubioside chloride inhibits the enzyme activity by competing with the substrate for the active site. 3. Cyanidin-3-O-sambubioside chloride has antioxidant activity and free-radical-scavenging property. 4. Cyanidin-3-O-sambubioside chloride is highly water-soluble and is easily degraded by hydrolysis and /or hydrogenation at temperatures >40°C. | |
