Products with Anti-metastatic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4391 | Lapachol |
| Lapachol shows both antimicrobial, trypanocidal and antiviral activities, it also shows antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. Probiotics are capable of converting Lapachol into the most effective cytotoxic compound against a breast cancer cell line. | |
| BCN4939 | Griffipavixanthone |
| 1. Griffipavixanthone can inhibit tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer. 2. Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. | |
| BCN4957 | Nitidine chloride |
| Nitidine chloride has protective effects on rats during myocardial ischemia/reperfusion, it also exerts an anti-inflammatory property by inhibiting TNF-α, IL-1β, and IL-6 production in association with reduced NF-κB and MAPK signaling pathways in RAW 264.7 cells. It has inhibitory effects on various tumors, such as renal cancer , breast cancer. | |
| BCN5224 | Magnolin |
| Magnolin has anti-inflammatory, anti-histaminic, and antioxidative effects, it might be a naturally occurring chemoprevention and therapeutic agent capable of inhibiting cell proliferation and transformation by targeting ERK1 and ERK2. Magnolin can ameliorate the renal tubular necrosis, apoptosis, and the deterioration of renal function, it reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. | |
| BCN5272 | Dihydroflavokawin B |
| Flavokawain A is an apoptotic inducer and immune- modulator ,it also shows anti-inflammatory, and anti-tumor activities.Flavokawain A can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.Flavokawain A may suppress LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages. | |
