Products with Anti-metastatic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6285 | Norisoboldine |
| Norisoboldine produces anti-inflammatory and anti-rheumatoid arthritis effects, it produces the analgesic effect in inflammatory pain by a mechanism related to the adenosine system. Norisoboldine alleviated joint destruction in AIA rats by reducing RANKL, IL-6, PGE2, and MMP-13 expression via the p38/ERK/AKT/AP-1 pathway, it decreased forskolin-evoked cyclic adenosine monophosphate levels in mouse spinal cord neuronal cultures through the adenosine A1 receptor. | |
| BCN6299 | Silymarin |
| Silymarin possesses hepatoprotective, antioxidant, anti-inflammatory and immunomodulatory properties. It is an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration. Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation. It inhibits PGE2 -induced cell migration through inhibition of EP2 signaling pathways (G protein dependent PKA-CREB and G protein-independent Src-STAT3). | |
| BCN6333 | Licochalcone B |
| Licochalcone B has antitumor, antimetastatic, cardioprotective, antioxidant, antiapoptotic, and anti-inflammatory effects, it can significantly inhibit LPS-induced phosphorylation at serine 276 and transcriptional activation of NF-KB. Licochalcone B can protect the liver from carbon tetrachloride (CCl4)-induced injury, the protection may be due to inhibition of p38 and NFκB signaling, which subsequently reduces inflammation in the liver. | |
| BCN6458 | Isorhynchophylline |
| 1. Isorhynchophylline exerts anticancer and anti-metastatic effects through regulation of multiple signaling cascades in hepatocellular carcinoma cells. 2. Isorhynchophylline exerts neuroprotective effect against Aβ 25-35-induced neurotoxicity in vitro via PI3K/Akt signaling pathway. 3. Isorhynchophylline shows antidepressant-like effects, which are mediated, at least in part, by the inhibition of monoamine oxidases. 4. Isorhynchophylline shows inhibition on angiotensin II-induced proliferation in rat vascular smooth muscle cells. 5. Isorhynchophylline shows anti-inflammatory effects in mouse N9 microglial cells. 6. Isorhynchophylline plays a remarkably preventive role in cardiac arrhythmias through the inhibition of calcium currents in rats and guinea pigs. | |
| BCN6679 | Licoricidin |
| 1. The hexane-ethanol extract of Glycyrrhiza uralensis, which contains licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells. 2. Licoricidin inhibits lung metastasis of 4T1 mammary carcinoma cells, which may be mediated via inhibition of cancer cell migration, tumor angiogenesis, and lymphangiogenesis. 3. Licoricidin and licorisoflavan A are effective in inhibiting the growth of all three bacterial species(Porphyromonas gingivalis, Prevotella intermedia and Solobacterium moorei), with minimal inhibitory concentrations in the range of 2-80 ug /ml, they have a potential for reducing bacterial volatile sulfur compounds (VSCs) production and therefore for controlling halitosis. 4. Licoricidin blocks UVA-induced photoaging via ROS scavenging,this activity converges to limit the activity of MMP-1, suggests that licoricidin may be considered as an active ingredient in new topically applied anti-ageing formulations. 5. Licoricidin and licorisoflavan A have potential for the development of novel host-modulating strategies for the treatment of cytokine and/or MMP-mediated disorders such as periodontitis. | |
