Products with Anti-mutagenic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5596 | Robinetin |
| 1. Robinetin has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with high efficiency. 2. Robinetin leads to the occurrence of positive induced circular dichroism (ICD) bands in the near ultra-violet (UV) region. 3. Robinetin has anti-mutagenesis and anti-promotion effects, diminishes ornithine decarboxylase activity induction at 6 h after 12-O-tetradecanoyl phorbol-13-acetate. | |
| BCN5730 | Galangin |
| Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity. Galangin has anti-proliferation, anti-metastatic, anti-inflammatory, vasorelaxant, antiviral, anti-allergic inflammatory,anti-obesity effects; it may be a potential candidate for the treatment of vitiligo. Galangin can inhibit Topo I activity and reduce the unwinding rate of single stranded DNNA in tumor cells, which plays an important role in induction of A549 and H46 cell apoptosis. Galangin shows an inhibitory effect on acetylcholinesterase (AChE) activity with the IC(50) of 120 microM; it also inhibits ERK, NF-κB-p65 and proinflammatory gene expression. | |
| BCN5928 | (+)-Gallocatechin |
| (+)-Gallocatechin as a bio-antimutagenic compound against UV-induced mutation in Escherichia coli. It is potent in scavenging Fremy’s salt, a synthetic free radical, it possesses antioxidant capacities that is higher or comparable to that of ascorbic acid or Trolox. | |
| BCN6250 | Hispidulin |
| Hispidulin has anti-oxidative, anti-inflammatory, anti-cancer, antiepileptic, neuroprotective, anti-osteoporotic and bone resorption attenuating effects, it targets the VEGF receptor 2-mediated PI3K/Akt/mTOR signaling pathway in endothelial cells, leading to the suppression of pancreatic tumor growth and angiogenesis. Hispidulin can ameliorate high glucose-mediated endothelial dysfunction via inhibiting PKCβII-associated NLRP3 inflammasome activation and NF-κB signaling, it has potential application in the prevention and treatment of diabetic vascular complications. Hispidulin can inhibit platelet aggregation by elevating cAMP levels by a mechanism different from that of theophylline or PGE1. | |
| BCN6695 | Licoisoflavone B |
| 1. Licoisoflavone B exhibits antimutagenic activity against carcinogenic N-methyl-N-nitrosourea (MNU), it is important to prevent DNA damage by N-nitrosamines for cancer chemoprevention. 2. Licoisoflavone B is an inhibitor of germ tube growth in the arbuscular mycorrhizal (AM) fungus Gigaspora margarita, it can strongly inhibit germ tube growth at 0.63 ug/disc, and it can completely inhibit hyphal branching induced by a lupin strigolactone, orobanchyl acetate, in G. margarita at 0.16 ug/disc. 3. Licoisoflavone B exhibits inhibitory activity against the growth of Helicobacter pylori in vitro, it also shows anti-H. pylori activity against a clarithromycin (CLAR) and amoxicillin (AMOX)-resistant strain. 4. Licoisoflavones A and B show inhibitory effects on copper-ion-induced protein oxidative modification of mice brain homogenate, in vitro. | |
