Products with Anti-mutagenic Bioactivity

Explore BioCrick products associated with Anti-mutagenic biological activity, including catalog numbers, product names and available bioactivity information.

Cat. No.	Product Name
BCN2594	Sesamol
Sesamol is regarded as a major antioxidant component in the oil with chemoprevention, radioprotective efficacy, anti-antiinflammary, antimutagenic, and antihepatotoxic activities. Sesamol inhibits melanin biosynthesis by down-regulating tyrosinase activity and melanin production via regulation of gene expression of melanogenesis-related proteins through modulation of MITF activity, which promotes phosphorylation of p38 and JNK in melan-a cells.
BCN2939	Cassiaside
1. Cassiaside and emodi show mixed-type inhibition against β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1). 2. Cassiaside demonstrates significant antimutagenic activity. 3. Cassiaside shows 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical scavenging effect. 4. Cassiaside has significant hepato-protective effects against galactosamine damage, which is higher than that of silybin from Silybum marianum.
BCN3088	Asperulosidic acid
1. Asperulosidic acid has been recently used in chinese medicine as a useful drug against some tumors. 2. Asperulosidic acid has anticlastogenic activity, since the anticlastogenic irridoids have an alpha-unsaturated carbonyl group, this structure is considered to play an important role in the anticlastogenicity. 3. Asperulosidic acid, and 6-O-(beta-D-glucopyranosyl)-1-O-octanoyl-beta-D-glucopyranose are effective in suppressing 12-O-tedtradecanoylphorbol-13-acetate (TPA)- or epidermal growth factor (EGF)-induced cell transformation and associated AP-1 activity. 4. Asperulosidic acid can inhibit the seed germination and growth of seedlings of large crabgrass.
BCN3331	Inotodiol
1. Inotodiol shows significant anti-tumor and anti-tumor promoting activities, including human cervical cancer. 2. Inotodiol inhibits cell proliferation through apoptosis induction by activating caspase-3. 3. Inotodiol can inhibit proliferation and induce the apoptosis of A549 cells, and its molecular mechanism may be associated with the up-regulating expression of p53 and bax proteins and down-regulating expression of Bcl-2 protein, which arrested A549 cells in S phase.
BCN3408	Gentisic acid
Gentisic acid, an active metabolite of salicylic acid degradation, has a broad spectrum of biological activity, such as antibiotic, anti-inflammatory, antirheumatic and antioxidant properties; it also has antimutagenic/protective effects that may contribute to human health. Gentisic acid has protective effect against cyclophosphamide induced genotoxicity and hepatotoxicity in Swiss albino mice.

Anti-mutagenic Bioactivity Products