Products with Anti-nociceptive bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5539 | Damnacanthal |
| 1. Damnacanthal possesses anti-cancer property, can treat or prevent hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis. 2. Damnacanthal inhibits mast cell activation induced by different stimuli and open a new window for the use of this compound as a mast cell stabilizer. 3. P53-mediated Damnacanthal induces apoptosis through the activation of p21 and caspase-7. 4. Damnacanthal possesses anti-inflammatory property, can inhibit the NF-κB/receptor-interacting protein-2/caspase-1 signal pathway by inhibiting p56lck tyrosine kinase . 5. Damnacanthal and noni extract supplements containing it could be potentially interesting for the treatment and/or chemoprevention of hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis. 6. Damnacanthal has antinociceptive and anti-inflammatory actions in mice. 7. Damnacanthal can act as an immunomodulatory agent which may be very useful for maintaining a healthy immune system. | |
| BCN5544 | Atranorin |
| 1. Atranorin shows significant antinociceptive and antiinflammatory activity. 2. Atranorin has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent depending on the radical, also, it will exert cytoprotective effects on cells under oxidative stress induced by H(2)O(2). 3. Atranorin has suppression of viability and proliferation in tumour cell lines. | |
| BCN5790 | Aurantiamide |
| 1. Aurantiamide acetate may suppress the growth of malignant gliomas by blocking autophagic flux. 2. Aurantiamide acetate has an anti-neuroinflammatory effect on LPS stimulation through its inhibition of the NF-κB, JNK and p38 pathways. 3. Aurantiamide acetate inhibits cysteine proteinases, in particular, cathepsin L (3.4.22.15) and B (3.4.22.1) with IC50 of 12 microM and 49 microM, respectively . 4. Aurantiamide acetate is the main active substance of EECTD, which has significant anti-inflammatory and antinociceptive activities. | |
| BCN6280 | Monotropein |
| Monotropein has anti-antiosteoporosis and anti-inflammatory activities, it exerts protective effects against IL-1β-induced apoptosis and catabolic responses on osteoarthritis chondrocytes and can increase osteoblastic bone formation and prevent bone loss in ovariectomized mice. | |
| BCN6576 | 8-Epideoxyloganic acid |
| 1. 8-Epideoxyloganic acid (oral) shows weak antinociceptive activity. 2. 8-Epideoxyloganic acid has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibly through modulation of NOX activity and/or the radical scavenging effect, and beta2 integrin expression in leucocytes. 3. 8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. | |
