Products with Anti-obesity bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5017 | Agrimol B |
| Agrimol B has antibacterial activity against Pseudomonas syringae pv. lacrymans (bacterial leaf spot pathogen), Ralstonia solanacearum (tomato bacterial wilt pathogen) and Pseudomonas syringae pv. tabaci (Tobacco wild fire pathogen). Agrimol B has a therapeutic potential on alleviating obesity, through modulation of SIRT1-PPARγ signal pathway. | |
| BCN5238 | Methyl orsellinate |
| 1. Methyl orsellinate is a phytotoxic compound, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, interact with bovine-brain calmodulin and inhibit the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase. 2. Methyl orsellinate exhibits antifungal activity. 3. Methyl orsellinate can inhibit PTP1B activity with 50% inhibitory concentration values of 277 +/- 8.6 microM, the selective inhibition of PTP1B has been widely recognized as a potential drug target for the treatment of type 2 diabetes and obesity, methyl orsellinate may can treat the type 2 diabetes and obesity. | |
| BCN5294 | Norathyriol |
| 1. Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability. 2. Norathyriol can improve the glucose utilization and insulin sensitivity by up-regulation of the phosphorylation of AMPK. 3. Norathyriol exerts a potent chemopreventive activity by inhibiting Akt activation in neoplastic cell transformation. 4. Norathyriol as a safe new chemopreventive agent that is highly effective against development of UV-induced skin cancer. 5. Norathyriol may be a dual, yet weak, cyclooxygenase and lipoxygenase pathway blocker, it has anti-inflammatory effect, and has inhibitory effect on the A23187-induced pleurisy and acetic acid-induced writhing response in mice. 6. Norathyriol can relax the rat thoracic aorta mainly by suppressing the Ca2+ influx through both voltage-dependent and receptor-operated calcium channels. | |
| BCN5351 | Anhydroicaritin |
| Anhydroicaritin exhibits immunosuppressive effects and has strong activity in scavenging DPPH radical. Anhydroicaritin can improve diet-induced obesity and hyperlipidemia and alleviate insulin resistance by suppressing SREBPs activation, it can serve as a leading compound for pharmacological control of metabolic diseases. Anhydroicaritin has the potential of stimulating the formation of mineralization nodules and further speeding up the formation of bone, it possesses significant protective effects on the zymosan-induced peritonitis mice, which may be associated with the regulation ofCa2+, influx in macrophages and iNOS expression. | |
| BCN5419 | Theaflavin |
| Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase, which has anti-inflammatory, antioxidative, anti-mutagenic, anti-HSV-1, and anti-carcinogenic properties. Theaflavin is active in the prevention of fatty liver and obesity, it can significantly reduce lipid accumulation, suppress fatty acid synthesis, and stimulate fatty acid oxidation. Theaflavin inhibits LPS-Induced IL-6, MCP-1, and ICAM-1 expression in bone marrow-derived macrophages through the blockade of NF-κB and MAPK signaling pathways; it also protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease. | |
