Products with Anti-osteoclastogenesis bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6047 | Rubiadin |
| Rubiadin has hepatoprotective, antioxidant, and antitumor promoting effects. Rubiadin can decrease bone loss through the inhibition of osteoclast formation,differentiation and bone resorption. | |
| BCN6272 | Diosgenin |
| Diosgenin possesses antivascular calcification , anti-osteoclastogenesis, anti-inflammatory and anticancer properties, it has favorable effects in the improvement of diabetes and regulation of lipid metabolism. Diosgenin treated inflammation-related disorders through the blockade of cAMP, PKA, cPLA2, PAK, Akt and MAPKs signaling pathways. Diosgenin may decrease the risk of developing dementia of opiate abusers with HIV infection and the ApoE4 allele. | |
| BCN6328 | (-)-Gallocatechin gallate |
| (-)-Gallocatechin gallate has cancer-preventive activities, it can precipitate cholesterol, decreasee osteoclastogenesis at 20 microM. | |
| BCN6506 | 1-Hydroxy-2,3,4,7-tetramethoxyxanthone |
| 1. 1-Hydroxy-2,3,4,7-tetramethoxy-xanthone can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 2. 1-Hydroxy-2,3,4,7-tetramethoxyxanthone can effectively inhibit the osteoclast differentiation in a co-culture system with mouse osteoblastic calvarial cells and bone marrow cells. | |
| BCN6569 | 1-Hydroxy-2,3,5-trimethoxyxanthone |
| 1. 1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. 2. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-culture system with mouse osteoblastic calvarial cells and bone marrow cells, it exhibits significant inhibition of osteoclast differentiation even at a low concentration (0.01 ug/mL) in a dose-dependent manner, and it can significantly reduce the pit formation on the dentine slice compared with the control group. 3. HM-1 can protect mice from the acute lung injury induced by ipopolysaccharide (LPS), which is relative to the increasing of IκB-α protein expression and the suppressing of inducible nitric oxide synthase and cyclooxygenase-Ⅱ protein expression. | |
