Products with Anti-trypanosoma bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2172 | Canertinib |
| Canertinib is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. Canertinib displays anti-proliferative and pro-apoptotic effects in human myeloid leukemia cells devoid of ErbB-receptors, downregulates important signaling pathways and activates caspase-mediated intrinsic apoptosis pathway in human T-cell leukemia cells. | |
| BCN2302 | Solasonine |
| Solasonine displays leishmanicidal activity against promastigote forms of L. amazonensis. | |
| BCN2338 | 1,2,3,4,6-O-Pentagalloylglucose |
| 1,2,3,4,6-O-Pentagalloylglucose(PGG) has antimutagenic, anti-proliferative, anti-invasive,vasodilatory, anti-inflammatory, anti-parasitic, anti-HBV, and antioxidant activities. PGG may serve as a model for the development of new types of anti-diabetic and anti-metabolic syndrome therapeutics. PGG dilates vascular smooth muscle and suppresses the vascular inflammatory process via endothelium-dependent nitric oxide (NO)/cGMP signaling; it also has inhibition of inducible NO synthase and cyclooxygenase-2 activity. | |
| BCN2477 | 1,2-Dihydrotanshinquinone |
| 1. 1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. | |
| BCN2622 | Columbin |
| Columbin has anti-inflammation activity, it has chemopreventive ability against human colon cancer, it also can inhibit growth of culture forms of Trypanosoma brucei. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion. | |
