Products with Anti-trypanosoma bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1650 | Camaric acid |
| 1. Camaric acid, lantanilic acid, and oleanolic acid possess nematicidal activity, they exhibit 95%, 98% and 70% mortality respectively against root-knot nematode Meloidogyne incognita at 0.5% concentration. 2. Camaric acid shows antibacterial activity against Staphylococcus aureus and methicillin resistant S. aureus with IC50 values 8.74 and 8.09 uM, respectively, it also shows moderate antileishmanial activity and highly potent antitrypanosomal activity. 3. Camaric acid shows anticancer activity. 4. Camaric acid shows significant topical anti-inflammatory activity with IC50 value of 0.67 mg/ear in the assay of TPA mouse ear oedema model. | |
| BCN1717 | Lupenone |
| Lupenone and lupeol inhibit protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 13.7 ± 2.1 and 5.6 ± 0.9 uM, respectively, they are non−competitive inhibitors of PTP1B, and PTP1B appears to be an attractive target for the development of new drugs for type 2 diabetes and obesity. Lupenone stimulates melanogenesis by increasing the tyrosinase enzyme expression via mitogen-activated protein kinase phosphorylated extracellular signal-regulated kinases 1 and 2 phosphorylation inhibition. A 1 : 4 mixture of Lupenone and caryophyllene oxide shows trypanocidal activity. | |
| BCN2163 | Veraguensin |
| 1. Veraguensin shows activity against trypomastigote T. cruzi. 2. Veraguensin and galgravin can inhibit bone resorption and may offer novel compounds for the development of drugs to treat bone-destructive diseases such as osteoporosis. 3. Veraguensin shows high antileishmanial activity. | |
