Products with Anti-wrinkle bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2533 | Monomethyl lithospermate B |
| 1. Magnesium lithospermate B can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling. 2. Magnesium lithospermate B is an inhibitor of lipid peroxidation and scavenge superoxide anions and hydroxyl radicals both in vitro and ex vivo. 3. Magnesium lithospermate B can ameliorate cisplatin-induced injury in cultured renal epithelial cells. 4. Magnesium lithospermate B is a naturally occurring, new generation antioxidant that activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress.[ 5. Magnesium lithospermate B possesses inhibitory activity on Na+,K+-ATPase, it provides anti-ischemic neuroprotection in gerbilssubjected to focal ischemia and reperfusion. 6. Magnesium lithospermate B has protective effects against diabetic atherosclerosis via Nrf2-ARE-NQO1 transcriptional pathway.[6] 7. Magnesium lithospermate B has potent antifibrotic effect in intraperitoneal thioacetamide (TAA)-treated cirrhotic rats, and inhibits fibrogenic responses in hepatic stellate cells (HSCs). 8. Magnesium lithospermate B has depressor action on blood pressure in spontaneously hypertensive rats. 9. Magnesium lithospermate B may stimulate the synthesis of kallikrein and/or conversion to active kallikrein, thus improving renal function. 10.Magnesium lithospermate B has anti-wrinkle and anti-aging effects on skin. | |
| BCN2706 | Ginsenoside Rg6 |
| Ginsenoside Rg6 can inhibit JK cell proliferation in human lymphocytoma and induce its apoptosis, the mechanism may through mitochondrial dysfunction and an increase of Bax expression and decrease of Bcl-2 expression. | |
| BCN5166 | Communic acid |
| 1. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic ingredients, as they suppress UVB-induced MMP-1 expression. 2. Communic acid has antibacterial activity, including against mycobacterial. 3. trans-Communic acid exhibits protective effects against UVB-induced skin aging by suppressing UVB-induced MMP-1 expression. 4. trans-Communic acid shows considerable cytotoxicity against four human cancer cell lines in vitro. 5. trans-Communic acid shows good activity against Mycobacterium aurum (MIC of 13.2 microM). | |
| BCN5290 | Ziyuglycoside I |
| Ziyuglycoside I has anti-wrinkle activity, could be used as an active ingredient for cosmetics. | |
| BCN5488 | Genkwanin |
| Genkwanin has antitumor, and anti-inflammatory activities, it enhances host immunity, decreases the inflammatory cytokine levels, and regulates the miR-101/MKP-1/MAPK pathway.Genkwanin may have anti-skin ageing activity, it can up-regulate the transcriptional activation of human type vii collagen gene promoter, stimulating the formation of anchoring fibrils at the basement membrane zone in skin contributed to preventing skin ageing; it also induces a decrease of melanin synthesis by inhibiting tyrosinase activity, it could as skin whitening agent in cosmetic preparations. | |
