Products with Anticancer Bioactivity

Explore BioCrick products associated with Anticancer biological activity, including catalog numbers, product names and available bioactivity information.

Cat. No.	Product Name
BCN5512	Quinovic acid
1. Quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by inducing apoptosis through modulation of NF-κB, suggests that it may become a potential therapeutic agent for the prevention and/or treatment of this cancer. 2. Quinovic acid shows some anti-tumour activities.
BCN5513	Hederagenin
Hederagenin shows anti-cancer,anti-inflammatory, antidepressant-like ,anticomplementary, and antimutagenic effects, it can evoke hemolysis on the erythrocytes, and has cytotoxic on various tumor cell lines, P-388, L-1210, U-937, HL-60, SNU-5 and HepG2. Hederagenin can inhibit LPS-stimulated expression of iNOS, COX-2, and NF-κB, regulate monoamine neurotransmitters and 5-HTT mRNA expression.
BCN5520	alpha-Lapachone
1. alpha-Lapachone is an "irreversible" inhibitor of topoisomerase II, it can inhibit initial non-covalent binding of topoisomerase II to DNA and, and can induce religation of DNA breaks (even in pre-established ternary complexes) before dissociating the enzyme from DNA. 2. alpha-Lapachone shows an approximately trypanocidal activity against Trypanosoma cruzi. 3. alpha-Lapachone has antineoplastic activity.
BCN5524	Betulinic acid
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, immunomodulatory, anti-inflammatory and anti-tumor properties.Betulinic acid is a selective inducer of apoptosis in tumor cells, it inhibits activation of NF-kappaB and NF-kappaB-regulated gene expression induced by carcinogens and inflammatory stimuli.
BCN5528	Betulin
Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line. Betulin has hypoglycemic, antineoplastic, anti-HIV, antimalarial and anti-inflammatory activities. Betulin can improve hyperlipidemia and insulin resistance and reduce atherosclerotic plaques. Betulin inhibits pro-inflammatory cytokines expression and NF-κB signaling activation through STAT3 signaling, it is associated with activation of AMP kinase and inhibition of mTOR/p70S6K/pS6 signaling in these cells.

Anticancer Bioactivity Products