Products with Anticancer bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5421 | Theaflavin-3'-gallate |
| Theaflavin-3'-gallate, acts as prooxidants and induces oxidative stress, with carcinoma cells more sensitive than normal fibroblasts. | |
| BCN5423 | Vitexin |
| Vitexin, an HIF-1alpha inhibitor, which has anticonvulsant, anti-depressant, anti-glycation, spasmolytic, anti-metastatic, antitumor, anti-inflammatory and antinociceptive activities. Vitexin can be effectively used for the prevention of UV-induced adverse skin reactions such as free radical production and skin cell damage; it non-competitively inhibits Ach but not the Ca(2+) influx. | |
| BCN5452 | Methyllinderone |
| 1. Methyllinderone has antioxidant property. 2. Methyllinderone is a human chymase inhibitor. 3. Methyllinderone shows moderate to weak antifungal activities against various pathogenic fungi. 4. Methyllinderone can inhibit farnesyl protein transferase with IC50 value of 55.3+/-4.1microM and selectively inhibit the growth of H-ras-transformed rat-2 cell lines with a GI50 value of 0.3 microM. 5. Methyllinderone shows significant cytotoxicity against mouse melanoma (B16-F10), human acetabulum fibrosarcoma (HT1080), and choronic myelogenous leukemia (K562) cancer cell lines with ED(50) values of 2.2, 2.5, 8.3 mug/ml, respectively. | |
| BCN5456 | Yatein |
| 1. Yatein is a lignan precursor of podophyllotoxin, a key agent in anticancer drugs. 2. Yatein can significantly suppress HSV-1 multiplication in HeLa cells without apparent cytotoxicity. | |
| BCN5459 | Nerolidol |
| Nerolidol, a sesquiterpene used as a food-flavoring agent and currently under testing as a skin penetration enhancer for the transdermal delivery of therapeutic drugs. Nerolidol shows anti-cancer, sedative, antiulcer, antifungal, and antifeeding effects. Nerolidol can inhibit the growth of Leishmania amazonensis, L. braziliensis, and L. chagasi promastigotes and L. amazonensis amastigotes with in vitro 50% inhibitory concentrations of 85, 74, 75, and 67 uM, respectively. | |
