Products with Anticancer bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5579 | Sphondin |
| 1. Sphondin possesses an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells through suppression of NF-kappaB activity, it may have the therapeutic potential as an anti-inflammatory drug on airway inflammation. 2. Sphondin, 8-methoxypsoralen, and khellin have delayed phototoxic effects inAedes aegypti. 3. Sphondin has NO production inhibitory activity, due to the effect of iNOS expression, it may act as a potent inhibitor of NO production under tissue-damaging inflammatory conditions. 4. Sphondin may have anticonvulsant activity. 5. Sphondin shows anti-proliferative activity and causes G2/M arrest at concentrations of 0.05-15.0 uM, it may have anti-tumor effects. | |
| BCN5581 | Osthol |
| Osthol is a natural antihistamine alternative, may be a potential inhibitor of histamine H1 receptor activity. Osthol has toxicity, may be used as bio-pesticides. Osthol is an inhibitor of human Pgp and multidrug efflux pumps of Staphylococcus aureus , reversing the resistance against frontline antibacterial drugs.Osthol has anti-allergic, antiosteoporosis, anti-fatty liver, antitumor, and cardioprotective effects. Osthol inhibits hepatic SREBP-1c/2 mRNA expressions and subsequent modulation of SREBP-1c/2-mediated target genes such as FAS, CYP7A and LDL receptor; it can stimulate the osteoblastic differentiation of rat calvarial osteoblast cultures by the BMP-2/p38MAPK/Runx-2/osterix pathway. | |
| BCN5582 | Bergapten |
| Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication. Bergapten has anti-inflammatory and anti-tumor agent, it exhibits significant inhibition of the production of pro-inflammatory cytokines, namely tumour necrotic factor-α(TNF-α) and interleukin-6 (IL-6) by peripheral blood mononuclear cells (PBMCs) stimulated with lipopolysaccharide in a concentration-dependent manner. Bergapten effectively prevents LPS-induced osteoclastogenesis, bone resorption and survival via apoptotic response of osteoclasts and their precursors. | |
| BCN5590 | Daidzein |
| Daidzein is a natural isoflavone phytoestrogen and a PPAR activator, used as a component of foods and dietary supplements, it should be a promising feed additive for production of high-quality beef meat. Daidzein has antitumor, anti-fibrotic, anti-bone loss, and anti-inflammatory effects. Daidzein inhibits TLR4-MyD88-NF-κB pathway. | |
| BCN5591 | Pinoresinol |
| Pinoresinol has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitric oxide release and to reduce oxidative stress preserving pial blood flow distribution; it may exert pharmacologically interesting effects via modulation of the insulin-like signalling pathway in C. elegans. Pinoresinol causes an upregulation of the CDK inhibitor p21(WAF1/Cip1) both at mRNA and protein levels, inhibits NF-kappaB and activating protein 1 (AP-1). | |
