Products with Antidepressant bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2363 | Turkesterone |
| 1. Turkesterone is a phytoecdysteroid possessing an 11alpha-hydroxyl group, also is an analogue of the insect steroid hormone 20-hydroxyecdysone. 2. Turkesterone has immunomodulating and antistress activity, can increase the adaptation capacity of mice under immobilization-induced stress conditions. | |
| BCN2373 | Crocin |
| Crocin is a water-soluble carotenoid pigment of saffron (Crocus sativus L.), it has been used as a spice for flavoring and coloring food preparations. Crocin has anti-inflammatory, anti-oxidative, anti-apoptotic, anti-asthma, anti-cancer, and hypolipidemic effects. Crocin improves toxic effects of diazinon via reducing lipid peroxidation and restoring altered contractile and relaxant responses in rat aorta; it also protects retinal photoreceptors against light-induced cell death. Crocin can also promote ovarian cancer HO-8910 cell apoptosis, most likely by increasing p53 and Fas/APO-1 expression, and then activating the apoptotic pathway regulated by Caspase-3.Crocin has antihyperlipidemic, antidepressant, anti-inflammatory and anti-apoptotic effects, it has a wide spectrum of targets including iNOS, caspase, CREB, BDNF and VGF. | |
| BCN2533 | Monomethyl lithospermate B |
| 1. Magnesium lithospermate B can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling. 2. Magnesium lithospermate B is an inhibitor of lipid peroxidation and scavenge superoxide anions and hydroxyl radicals both in vitro and ex vivo. 3. Magnesium lithospermate B can ameliorate cisplatin-induced injury in cultured renal epithelial cells. 4. Magnesium lithospermate B is a naturally occurring, new generation antioxidant that activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress.[ 5. Magnesium lithospermate B possesses inhibitory activity on Na+,K+-ATPase, it provides anti-ischemic neuroprotection in gerbilssubjected to focal ischemia and reperfusion. 6. Magnesium lithospermate B has protective effects against diabetic atherosclerosis via Nrf2-ARE-NQO1 transcriptional pathway.[6] 7. Magnesium lithospermate B has potent antifibrotic effect in intraperitoneal thioacetamide (TAA)-treated cirrhotic rats, and inhibits fibrogenic responses in hepatic stellate cells (HSCs). 8. Magnesium lithospermate B has depressor action on blood pressure in spontaneously hypertensive rats. 9. Magnesium lithospermate B may stimulate the synthesis of kallikrein and/or conversion to active kallikrein, thus improving renal function. 10.Magnesium lithospermate B has anti-wrinkle and anti-aging effects on skin. | |
| BCN2571 | L-Theanine |
| L-Theanine is a relaxing and nondietary amino acid found pretty much exclusively in teas from Camellia sinensis. It is known to promote relaxation and improve concentration and learning ability and has neuroprotective effects. L-Theanine heals gastric ulcer and prevents CCl4-induced experimental hepatic cirrhosis in rats by blocking the main pro-inflammatory and pro-fibrogenic signals. L-Theanine can significantly alleviate the adverse oxidative effect. | |
| BCN2633 | 5-Isopropyl-2-methylphenol |
| 5-Isopropyl-2-methylphenol presents anxiolytic, antinociceptive, and antidepressant effects, it seems to be dependent on its interaction with the dopaminergic system, but not with the serotonergic and noradrenergic systems. | |
