Products with Antidepressant Bioactivity

Explore BioCrick products associated with Antidepressant biological activity, including catalog numbers, product names and available bioactivity information.

Cat. No.	Product Name
BCN5977	Hypericin
Hypericin is a photosensitive antiviral with anticancer and antidepressant agent . It can inhibit tyrosine kinases with IC50 of 7.5 μM. It can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion, and inhibit RANKL-mediated osteoclastogenesis via affecting ERK signalling in vitro and suppresses wear particle-induced osteolysis in vivo.
BCN6113	Auraptenol
1. Auraptenol possesses robust antidepressant-like efficacy in mice. 2. Auraptenol attenuates vincristine-induced mechanical hyperalgesia through serotonin 5-HT1A receptors, it has potential to be a novel analgesic for the management of neuropathic pain. 3. Auraptenol shows high inhibitory activities against larval settlement of Balanus albicostatus with EC50values of 3.38 ug m/L.
BCN6165	Protopine
Protopine acts as a potent inhibitor of thromboxane synthesis and PAF with hepatoprotective, antidepressant, antioxidant, antispasmodic and relaxant properties. Protopine is also a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Protopine blocks phosphorylation of mitogen-activated protein kinases (MAP kinases) and also blocks activation of a nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB).
BCN6270	Cytisine
Cytisine is a nicotinic acetylcholine receptor agonist, has been widely used for central nervous system (CNS) diseases treatment. It is a partial agonist at alpha4/beta2 nAChRs, and a full agonist at alpha3/beta4 and alpha7 nAChRs, has antidepressant-like properties in several rodent models of antidepressant efficacy.
BCN6308	Synephrine
p-Synephrine is widely used in weight loss and weight management as well as in sports performance products, which has antidepressant-like effects in the murine models of forced swimming and tail suspension, it also exerts potent anti-inflammatory effects by inhibition of the NF-κB signaling pathway. Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway.

Antidepressant Bioactivity Products