Products with Antiviral bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4161 | Ursonic acid |
| Ursolic acid, a naturally occurring triterpenoid, induces the apoptosis of human cancer cells through multiple signaling pathways. Ursonic acid has antiviral activity against Herpes simplex virus types I and II in vitro; it also could be used in preparation of depression treatment medicine. | |
| BCN4167 | Mulberrin |
| Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8 ±1.5 μM; it also as HIV-1 reverse transcriptase inhibitor. Mulberrin has significantly reduced role on blood sugar of type II diabetes model of rats. | |
| BCN4179 | beta-Amyrone |
| 1. beta-Amyrone has antifungal activity. 2. beta-Amyrone exhibits anti-α-glucosidase inhibitory activity and moderate anti- acetylcholinesterase (AChE) activity. 3. beta-Amyrone shows a moderate activity against Chikungunya virus replication (EC50 =86 uM). | |
| BCN4219 | Psoralen |
| Psoralen is a naturally occurring furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen has immunomodulatory properties on Th2 response in vitro, it can remit the degeneration of lumbar intervertebral disc induced by IL-1β to some extent, and affect the related factors of IL-1β signaling pathway. Psoralen may be feasible for reversing the multidrug resistance by inhibiting ABCB1 gene and protein expression. Psoralen ultraviolet A is an effective treatment for psoriasis. | |
| BCN4222 | Moronic acid |
| 1. Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. 2. Moronic acid is a new structural lead for anti-EBV drug development, can substantially reduce the numbers of EBV particles produced by the cells after lytic induction. 3. Moronic acids inhibits the capacity of Rta to activate a promoter that contains an Rta-response element, indicating that Moronic acid interferes with the function of Rta. 4. Moronic acid shows significant anti-HIV activity (EC(50) 186) and was modified to develop more potent anti-AIDS agents. 5.Morolic and moronic acids have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediated by inhibition of 11β-HSD 1 as indicated by in vitro. | |
