Products with Antiviral bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4113 | 6,7,8-Trimethoxycoumarin |
| 6,7,8-Trimethoxycoumarin has antiviral activity, it shows high anti-HRV-2 effect , with IC (50) value of 11.98 muM. It also can improve gastroprotective effects. | |
| BCN4115 | Chrysosplenetin |
| 1. Chrysosplenetin is a metabolic inhibitor of artemisinin. 2. Chrysosplenetin and penduletin have strong activity in vitro against EV71 with low cytotoxicity. 3. Co-administration of artemisinin(ART) with chrysosplenetin(CHR) in ratio of 1:2 achieved a synergic anti-malarial effect partly because of the noncompetitive or uncompetitive inhibition of CHR of drug-metabolism enzymes, especially CYP3A which is closely related to the auto-induction of ART. | |
| BCN4135 | Vitexilactone |
| 1. Vitexilactone dramatically induces apoptosis both on tsFT210 and K562 cells at higher concentrations while at lower concentrations it inhibits the cell cycle progression of both tsFT210 and K562 cells at the G0/G1 phase; it is one anticancer component of Vitex trifolia L., which exerts its anti-proliferative effect on cancer cells through inducing apoptosis and inhibiting the cell cycle. 2. Vitexilactone has trypanocidal activity, the minimum lethal concentration against epimastigotes of Trypanosoma cruzi is 66 microM . 3. Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse transcriptase. | |
| BCN4141 | Furomollugin |
| 1. Furomollugin has antiviral activity, it can strongly suppress the secretion of hepatitis B surface antigen (HBsAg), with IC50 = 2.0 micrograms/mL, in human hepatoma Hep3B cells. | |
| BCN4149 | Helichrysetin |
| 1. Helichrysetin has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29, suggests that it has great potentials for development as an anticancer agent. 2. Helichrysetin has mild anti-HIV-1 PR activity. | |
