Products with Cardioprotective Bioactivity

Explore BioCrick products associated with Cardioprotective biological activity, including catalog numbers, product names and available bioactivity information.

Cat. No.	Product Name
BCN5601	Chrysoeriol
1. Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilator effect. 2. Chrysoeriol can potently inhibit the induction of nitric oxide synthase by blocking activator protein 1 (AP-1) activation and its anti-inflammatory effects. 3. Chrysoeriol can potentially serve as a novel cardioprotective agent against doxorubicin (DOX)-induced cardiotoxicity without affecting the antitumor activity of DOX. 4. Chrysoeriol can induce nod genes in rhizobium meliloti. 5. Chrysoeriol can inhibit the downstream signal transduction pathways of platelet-derived growth factor (PDGF)-Rbeta, including ERK1/2, p38, and Akt phosphorylation, suggests that chrysoeriol may be used for the prevention and treatment of vascular diseases and during restenosis after coronary angioplasty. 6. Chrysoeriol can protect MC3T3-E1 cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation.
BCN5628	Echinocystic acid
Echinocystic acid has cardioprotective, hypolipidemic, anti-tumor, anti-inflammatory and antioxidant effects, it displays substantial inhibitory activity on HCV entry.Orally administered lancemaside A may be metabolized to echinocystic acid, which may be absorbed into the blood and ameliorate memory and learning deficits by inhibiting AChE activity and inducing BDNF and p-CREB expressions.Orally administered lancemaside A may be metabolized to echinocystic acid, which may be absorbed into the blood and ameliorate memory and learning deficits by inhibiting AChE activity and inducing BDNF and p-CREB expressions.
BCN5657	Hesperetin
Hesperetin has antioxidative and anti-inflammatory effects, it inhibits vascular formation by endothelial cells via the inhibition of the PI3K/AKT, ERK and p38 MAPK signaling. Hesperetin-mediated apoptosis of MCF-7 cells involves accumulation of ROS and activation of ASK1/JNK pathway, it induces apoptosis in triple negative breast cancer MDA-MB-231 cells via intrinsic pathway via activation of caspase -9 and -3 and increase in Bax:Bcl-2 ratio.
BCN5776	8-O-Acetylshanzhiside methyl ester
8-O-Acetylshanzhiside methyl ester(ND01) has potential against cerebral ischemic injury and experimental myocardial ischemia injury, it can increase angiogenesis and improve functional recovery after stroke. ND01 protects diabetic brain against I/R injury by alleviating diabetic cerebral I/R injury and attenuating blood–brain barrier (BBB) breakdown, and its protective effects may involve HMGB-1 and NF-κB signalling pathway.
BCN5902	Scutellarin
1. Breviscapine can treat coronary disease . 2. Breviscapine inhibits the increased levels of 4-HNE and 8-OHdG, and enhances the antioxidant capacity of cortex tissue. 3. Breviscapine can reduce the inflammatory response, protect the lungs from inflammatory cascade responses by inhibiting the expression of IL-18 and ICAM-1. 4. Breviscapine injection significantly ameliorates neurologic deficit, reduces infarct volume and water content, and suppresses the levels of NSE in a time-dependent manner, may the mechanism is by up-regulating the expression of Nrf2/HO-1 pathway .5.Scutellarin has many pharmacological effects, such as antioxidant, antitumor, antiviral, neuroprotection and antiinflammatory activities. It down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.

Cardioprotective Bioactivity Products