Products with Cardioprotective Bioactivity

Explore BioCrick products associated with Cardioprotective biological activity, including catalog numbers, product names and available bioactivity information.

Cat. No.	Product Name
BCN4004	Moracin O
1. Moracin O and moracin P exhibit potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. 2. Moracin O shows significant neuroprotective activity against glutamate-induced cell death in SK-N-SH cells. 3. Moracin O demonstrates a remarkable inhibition of the acetic acid-induced pain. 4. Moracin O has a strong protective influence against doxorubicin-induced cardiomyopathy in H9c2 cells with the EC50 value of 4.5 ± 1.3 uM.
BCN4327	Ursolic acid
Ursolic acid is a potential PPARγagonist, which has anti-tumor, chemopreventive, hepatoprotective, anti-inflammatory, antioxidant, antidepressant-like, antimicrobial activities, and anti-asthmatic effects. Ursolic acid also has antihyperlipidemic, hypoglycemic and direct cardiac effect, its antihypertensive effect is attributed to its potent diuretic-natriuretic-saluretic activity. Ursolic acid regulates NF-κB, VEGF, COX-2, Nrf2, ARE, IL-5, IL-13, IL-17and MAPK signaling pathways.
BCN4367	Visnagin
Visnagin has acute hypotensive, anti-inflammatory, and neuroprotective effects, it protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Visnagin can relax aortae previously contracted by noradrenaline, and weakly inhibit the hydrolytic activity of the cyclic nucleotide phosphodiesterase (PDE) isozymes (PDE5, PDE4, PDE3, cyclic GMP activated PDE2 and PDE1).
BCN4385	Rutaecarpine
Rutaecarpine is an inhibitor of COX-2 with an IC50 value of 0.28 μM, and is also a potent inhibitor of CYP1A2. Rutaecarpine has anti-atherosclerosis, immunosuppressive, anti-inflammatory, gastroprotective, vasorelaxing, antihypertensive and anti-platelet effects. Rutaecarpine has positive inotropic and chronotropic effects on the guinea-pig isolated right atria, possible involvement of vanilloid receptors. Rutaecarpine may be useful in the prevention of ultraviolet A-induced photoaging, it inhibits ultraviolet A-induced reactive oxygen species generation, resulting in the enhanced expression of matrix metalloproteinase (MMP)-2 and MMP-9 in human skin cells.
BCN4979	Rhynchophylline
Rhynchophylline, a noncompetitive antagonist of the NMDA receptor, which has anti-inflammatory, anti-hypertension, cardiacprotective and neuroprotective activities. Rhynchophylline can markedly inhibit rabbit platelet aggregation induced by ADP or thrombin possibly by depressing the inflow of Ca2+ and the rise of the cytoplasmic free calcium level in platelet.Rhynchophylline can reduce the systolic blood pressure (SBP) of spontaneously hypertensive rats (SHR) significantly, decrease plasma Ang II, ADMA, and AT1R levels, and promote serum NO and NOS levels, which has the protection of vascular endothelial function.

Cardioprotective Bioactivity Products