Products with DNA damaging agents bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2669 | Corydine |
| 1. Corydine shows antimicrobial activity. 2. Corydine shows antineoplastic activity. 3. Corydine is the adrenolytic and weak cholinergic agent. 4. Corydine shows irritant and respiratory stimulant and CNS depressant activities . 5. Injected intravenously in rabbits corydine produced an initial fall in blood pressure followed by a return to normal or above normal. | |
| BCN2758 | Hirsutine |
| Hirsutine has anticancer, cardioprotective, anti‑hypertensive and anti-arrhythmic activities, it also has vasodilatation activity, the mechanism is related to blockade of Ca2+ influx through L-type Ca2+ channels and inhibition of intracellular Ca2+ release may have no relationship with K+ channels. Hirsutine reduces the production of various neurotoxic factors in activated microglial cells and possesses neuroprotective activity in a model of inflammation-induced neurotoxicity. | |
| BCN2767 | Beta,beta-Dimethylacrylalkannin |
| Beta,beta-Dimethylacrylalkannin has radical scavenging activity, it exhibits inhibitory activities on PTP1B with IC50 values of 0.36±0.08 umol·L-1, it may be a new type of leading compounds for the treatment of diabetes. Beta,beta-Dimethylacrylalkannin has great potential as topo I inhibitors compared to other compounds and CPT-11, with 2-3uM inhibition value. Beta,beta-Dimethylacrylalkannin can be potential therapeutics against tumor cell growth because of its unique DNA damaging abilities additional to enzyme inhibition similar to those of doxorubicin. | |
| BCN3236 | Rabdosin B |
| 1. Rabdosin B at higher concentrations inhibits root growth by affecting both cell length in the mature region and division of meristematic cells. 2. Rabdosin B shows cytotoxic activity against three human tumour HepG2, GLC-82 and HL-60 cell lines. 3. Rabdosin B induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner. | |
| BCN3282 | Epinodosin |
| 1. Epinodosin has a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in Lactuca sativa L. seedlings. 2. Epinodosin induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner. | |
