Products with DNA damaging agents bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3391 | Effusanin B |
| 1. Effusanin B shows antibacterial activity. 2. Effusanin B exhibits DNA-damaging activity in assay which employes DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains. | |
| BCN3950 | Cepharadione A |
| 1. Cepharadione A, a naturally occurring DNA damaging agent. | |
| BCN4690 | Goniothalamin |
| 1. Goniothalamin enhances rather than inhibits the ATPase activity of a cyanobacterial Hsp90 (HtpG) and a yeast Hsp90, increases both K(m) and k(cat) of the Hsp90s. 2. Goniothalamin induces oxidative stresses and inhibits the expression of cell wall-associated proteins resulting in growth inhibition of Arabidopsis seedlings. 3. Goniothalamin has gastroprotective activity which is inhibited after pre-treatment with NEM (N-ethylmaleimide) and NSAID (non-steroidal anti-inflammatory drugs), highlighting the importance of sulfhydryl compounds and prostaglandins on Goniothalamin activity. 4. Goniothalamin is a natural product that has been demonstrated to induce apoptosis in various cancer cell lines, can induce cytotoxicity and apoptosis on RT4 cells, induce apoptosis on HepG2 liver cancer cells via induction of caspase-3 with less sensitivity on the cell line of Chang cells. | |
| BCN5081 | Vincosamide |
| 1. Vincosamide can effect relaxation of the supercoiled pBR322 plasmid DNA in the presence of Cu2+. | |
| BCN6561 | Edgeworin |
| 1. Edgeworin is a DNA polymerase beta (pol beta) inhibitor, it inhibits both the lyase and polymerase activities of DNA polymerase beta; it can potentiate the inhibitory action of the anticancer drug bleomycin in cultured A549 cells via an inhibition of DNA repair synthesis. | |
