Rabdosin B

CAS# 84304-92-7

Rabdosin B

Catalog No. BCN3236----Order now to get a substantial discount!

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Quality Control of Rabdosin B

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Chemical structure

Rabdosin B

3D structure

Chemical Properties of Rabdosin B

Cas No. 84304-92-7 SDF Download SDF
PubChem ID 14109027 Appearance Cryst.
Formula C24H32O8 M.Wt 448.5
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC(=O)OCC1C(CCC(C12COC(=O)C34C2C(CC(C3)C(=C)C4=O)O)OC(=O)C)(C)C
Standard InChIKey LUXJXSFHXOVGTA-DUAAMXSASA-N
Standard InChI InChI=1S/C24H32O8/c1-12-15-8-16(27)19-23(9-15,20(12)28)21(29)31-11-24(19)17(10-30-13(2)25)22(4,5)7-6-18(24)32-14(3)26/h15-19,27H,1,6-11H2,2-5H3/t15-,16+,17-,18+,19-,23+,24+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Rabdosin B

The herbs of Rabdosia japonica

Biological Activity of Rabdosin B

Description1. Rabdosin B at higher concentrations inhibits root growth by affecting both cell length in the mature region and division of meristematic cells. 2. Rabdosin B shows cytotoxic activity against three human tumour HepG2, GLC-82 and HL-60 cell lines. 3. Rabdosin B induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner.

Rabdosin B Dilution Calculator

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Rabdosin B Molarity Calculator

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Preparing Stock Solutions of Rabdosin B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2297 mL 11.1483 mL 22.2965 mL 44.5931 mL 55.7414 mL
5 mM 0.4459 mL 2.2297 mL 4.4593 mL 8.9186 mL 11.1483 mL
10 mM 0.223 mL 1.1148 mL 2.2297 mL 4.4593 mL 5.5741 mL
50 mM 0.0446 mL 0.223 mL 0.4459 mL 0.8919 mL 1.1148 mL
100 mM 0.0223 mL 0.1115 mL 0.223 mL 0.4459 mL 0.5574 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Rabdosin B

Regulation of cell division and growth in roots of Lactuca sativa L. seedlings by the Ent-Kaurene diterpenoid rabdosin B.[Pubmed:20376693]

J Chem Ecol. 2010 May;36(5):553-63.

Rabdosin B, an ent-kaurene diterpenoid purified from the air-dried aerial parts of Isodon japonica (Burm.f) Hara var. galaucocalyx (maxin) Hara, showed a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in lettuce seedlings (Lactuca sativa L.). Lower concentrations of Rabdosin B (20-80 microM) significantly promoted root growth, but its higher levels at 120-200 microM, by contrast, had inhibitory effects. Additionally, all tested concentrations (10-40 microM) inhibited root hair development of seedlings in a dose-dependent manner. Further investigations on the underlying mechanism revealed that the promotion effect of Rabdosin B at the lower concentrations resulted from increasing the cell length in the mature region and enhancing the mitotic activity of meristematic cells in seedlings' root tips. In contrast, Rabdosin B at higher concentrations inhibited root growth by affecting both cell length in the mature region and division of meristematic cells. Comet assay and cell cycle analysis demonstrated that the decrease of mitotic activity of root meristematic cells was due to DNA damage induced cell cycle retardation of the G(2) phase and S phase at different times.

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