Products with Neuroprotection bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6574 | Orsellinic acid |
| 1. Orsellinic acid is a novel benzoquinone ring precursor for antroquinonol and 4-acetylantroquinonol B, it formed from acetyl-coenzyme Q (CoQ) and malonyl-CoA via polyketide pathway. 2. Orsellinic acid can block platelet activating factor (PAF)-mediated neuronal apoptosis without affecting G-protein coupled receptor (PAFR)-mediated neuroprotection, it can effectively attenuate PAFR-independent neuronal apoptosis. | |
| BCN6770 | Brandioside |
| 1. Brandioside exhibits significant inhibition of advanced glycation end product formation with the IC50 value of 4.6-25.7 uM. 2. Brandioside significantly attenuates glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 microM. 3. Brandioside shows inhibition of smooth muscle cell proliferation, indicates that it may have preventative effects on arteriosclerosis. 4. Brandioside shows strong antioxidant effect. | |
| BCN6776 | Tyramine |
| Tyramine is a major mutagen precursor in soy sauce, being convertible to a mutagen by nitrite; it is the biological precursor of octopamine, both compounds are independent neurotransmitters, acting through various G-protein coupled receptors, they are antagonistic modulators of behavior and metabolism. | |
| BCN6790 | Dehydroglyasperin C |
| 1. Dehydroglyasperin C exhibits cancer chemopreventive potential via its inhibitory effect on TPA-induced neoplastic cell transformation and COX-2 modulation through regulation of the MKK4 and PI3K pathways. 2. Dehydroglyasperin C may inhibit microglia hyperactivation by increasing MKP-1 expression and acting as a potent anti-neurodegenerative agent. 3. Dehydroglyasperin C possesses potent antioxidant activity, suggests that it has protective effects against chronic diseases caused by reactive oxygen species as well as potential as an antioxidant food additive. 4. Dehydroglyasperin C can attenuate proliferation and migration induced by platelet-derived growth factor in human arterial smooth muscle cells. 5. Dehydroglyasperin C protects neuronal cells against glutamate-induced oxidative injury through the induction of HO-1 expression, which is, in turn, activated maybe through Nrf2-Keap1 and PI3K/AKT signaling pathways. 6. Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. | |
| BCN8086 | N-(3-Methoxybenzyl)palmitamide |
|
1. N-(3-Methoxybenzyl)palmitamide can counteract the toxicity produced by Aβ (25-35). 2. N-(3-methoxybenzyl)palmitamide is a promising inhibitor of fatty acid amide hydrolase (FAAH) and could potentially offer a good alternative for the treatment of pain, inflammation and CNS degenerative disorders. |
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