Products with Neuroprotection bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5902 | Scutellarin |
| 1. Breviscapine can treat coronary disease . 2. Breviscapine inhibits the increased levels of 4-HNE and 8-OHdG, and enhances the antioxidant capacity of cortex tissue. 3. Breviscapine can reduce the inflammatory response, protect the lungs from inflammatory cascade responses by inhibiting the expression of IL-18 and ICAM-1. 4. Breviscapine injection significantly ameliorates neurologic deficit, reduces infarct volume and water content, and suppresses the levels of NSE in a time-dependent manner, may the mechanism is by up-regulating the expression of Nrf2/HO-1 pathway .5.Scutellarin has many pharmacological effects, such as antioxidant, antitumor, antiviral, neuroprotection and antiinflammatory activities. It down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. | |
| BCN5903 | Fraxetin |
| Fraxetin has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a marked inhibitory effect on S.aureus proliferation. It increased the level of Nrf2/ARE, and HO-1, inhibit the formation of ROS, cytochrome c release, activation of caspase-3 and 9, and suppressed the up-regulation of Bax. | |
| BCN5904 | Esculin |
| Esculin has neuroprotective, anti-oxidative, and anti-apoptotic effects, it is a plant coumarin compound that occur naturally in dietary plants or when supplemented in the diet probably inhibit the survival of E. coli O157 in the gut. Esculin has protective effects on dopamine(DA)-induced cytotoxicity in human neuroblastoma SH-SY5Y cells. Esculin has a protective effect on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice, it can inhibit the Toll-like receptor-2 (TLR2), Toll-like receptor-4 (TLR4), myeloid differentiation primary response gene-88 (MyD88), and nuclear factor-κB (NF-κB) p65 in LPS-induced ALI. | |
| BCN5913 | 1,5-Dicaffeoylquinic acid |
| 1,5-Dicaffeoylquinic acid has neuroprotective, and antioxidant effects, it can prevent Aβ(42)-induced neurotoxicity through the activation of PI3K/Akt followed by the stimulation of Trk A, then the inhibition of GSK3β as well as the modulation of Bcl-2/Bax. 1,5-Dicaffeoylquinic acid has protective effects against MPP~+ induces neurotoxicity of PC12 Cells, it (50 umol/L) pretreatment can inhibit the MPP+-induced up-regulation of the expression of α-synuclein mRNA and protein. | |
