Products with Neurotoxin bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1238 | (+)-Bicuculline |
| (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.It is effective in vitro against spore germination of some plant pathogenic fungi, it can significantly inhibit spore germination of all the fungi at concentrations of 100-1000 ppm. | |
| BCN1840 | Janolusimide |
| 1. Janolusimide is a neurotoxin and atropine antagonist. | |
| BCN1841 | Lactacystin |
| 1. Lactacystin induces cell death and α-synuclein-positive inclusions in cytoplasm. 2. Lactacystin has diversified killing effects on gastric cancer cells, the mechanism may be related to induce the apoptosis by downregulation of nuclear factor kappa B viability. 3. Lactacystin is a selective UPS inhibitor recently used to destroy dopamine (DA) neurons in animal models of Parkinson's disease (PD); marked differences in the rotational response to apomorphine and l-DOPA suggest different mechanisms of neurodegeneration evoked by Lactacystin and 6-OHDA. | |
| BCN2145 | Trichodesmine |
| 1. Trichodesmine has greater lethality and neurotoxicity than monocrotaline, because of the two structural characteristics: (a) steric hindrance at position 14 of dehydroTrichodesmine results in greater resistance to hydrolysis, allowing more to be released from the liver and to be delivered to the brain; (b) the larger isopropyl substituent at position 14 of dehydroTrichodesmine renders the molecule more lipophilic, leading to greater penetration of the brain. | |
| BCN2203 | Corticosterone |
| Corticosterone, the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid, it is cytotoxic toward neurons, and the cytotoxic effect could be protected by Yokukansan. A delayed effect of elevated Corticosterone on breeding success rather than an immediate suppression of prolactin concentrations causing premature failure. | |
