Products with Neurotoxin bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2555 | Dencichin |
| 1. Dencichine is a neurotoxic agent . 2. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of coagulation system, platelet aggregation and fibrinolytic system. 3. Dencichine has renoprotective effect, it could significantly prevent the progression of diabetic nephropathy possibly attribute to down-regulation of the TGF-β/Smad pathway and rebalance the deposition and degradation of ECM proteins. 4. Dencichine is a haemostatic agent present , it is also a reported neurotoxic agent found in Lathyrus sativus (grass pea seed). | |
| BCN2726 | Dihydrorotenone |
| 1. Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome. 2. Dihydrorotenone induces human plasma cell apoptosis by provoking endoplasmic reticulum stress and induces cell death by activating the p38 but not the JNK signaling pathway. | |
| BCN5129 | Tutin |
| 1. Tutin in honey, is a plant-derived neurotoxin. | |
| BCN5412 | Rotenone |
| Rotenone is a mitochondrial complex I inhibitor that produces an animal model of Parkinson's disease. Rotenone-induced α-synuclein aggregation is mediated by the calcium/GSK3β signaling pathway. Rotenone can increase intracellular levels of the toxic dopamine metabolite 3,4-dihydroxyphenyl-acetaldehyde (DOPAL), via decreasing DOPAL metabolism by aldehyde dehydrogenase (ALDH) and decreasing vesicular sequestration of cytoplasmic dopamine by the vesicular monoamine transporter (VMAT). | |
| BCN5973 | Artemether |
| Artemether is a novel sonosensitizer,which has neurotoxicity, anti-schistosomiasis, anticancer and antitumor activities. It is an antimalarial for the treatment of resistant strains of falciparum malaria. | |
