Dihydrorotenone

CAS# 6659-45-6

Dihydrorotenone

Catalog No. BCN2726----Order now to get a substantial discount!

Product Name & Size Price Stock
Dihydrorotenone: 5mg Please Inquire In Stock
Dihydrorotenone: 10mg Please Inquire In Stock
Dihydrorotenone: 20mg Please Inquire Please Inquire
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Dihydrorotenone: 100mg Please Inquire Please Inquire
Dihydrorotenone: 200mg Please Inquire Please Inquire
Dihydrorotenone: 500mg Please Inquire Please Inquire
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Quality Control of Dihydrorotenone

Number of papers citing our products

Chemical structure

Dihydrorotenone

3D structure

Chemical Properties of Dihydrorotenone

Cas No. 6659-45-6 SDF Download SDF
PubChem ID 243725 Appearance Powder
Formula C23H24O6 M.Wt 396.43
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC(C)C1CC2=C(O1)C=CC3=C2OC4COC5=CC(=C(C=C5C4C3=O)OC)OC
Standard InChIKey DTFARBHXORYQBF-HBGVWJBISA-N
Standard InChI InChI=1S/C23H24O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,11,16,20-21H,8,10H2,1-4H3/t16-,20-,21+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Dihydrorotenone

The herbs of Derris trifoliata Lour.

Biological Activity of Dihydrorotenone

Description1. Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome. 2. Dihydrorotenone induces human plasma cell apoptosis by provoking endoplasmic reticulum stress and induces cell death by activating the p38 but not the JNK signaling pathway.
Targetsp21 | p53 | Akt | ERK | JNK | p38MAPK

Dihydrorotenone Dilution Calculator

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Dihydrorotenone Molarity Calculator

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Preparing Stock Solutions of Dihydrorotenone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5225 mL 12.6126 mL 25.2251 mL 50.4503 mL 63.0628 mL
5 mM 0.5045 mL 2.5225 mL 5.045 mL 10.0901 mL 12.6126 mL
10 mM 0.2523 mL 1.2613 mL 2.5225 mL 5.045 mL 6.3063 mL
50 mM 0.0505 mL 0.2523 mL 0.5045 mL 1.009 mL 1.2613 mL
100 mM 0.0252 mL 0.1261 mL 0.2523 mL 0.5045 mL 0.6306 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Dihydrorotenone

The natural pesticide dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway.[Pubmed:23922854]

PLoS One. 2013 Jul 26;8(7):e69911.

Dihydrorotenone (DHR) is a natural pesticide widely used in farming industry, such as organic produces. DHR is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome, however, it is not known whether DHR is toxic to other systems. In the present study, we evaluated the cytotoxicity of DHR on human plasma cells. As predicted, DHR impaired mitochondrial function by decreasing mitochondrial membrane potential in plasma cells. Because mito-dysfunction leads to unfolded protein response (UPR) and endoplasmic reticulum (ER) stress, we examined the signature proteins in ER stress, including GRP78, ATF4, and CHOP. After DHR treatment, these proteins were significantly upregulated. It is reported that activation of the mitogen-activated protein kinases p38 and JNK are involved in endoplasmic reticulum stress. However, in the subsequent study, DHR was found to activate p38 but not the JNK signaling. When pre-treated with p38 inhibitor SB203580, activation of p38 and cell apoptosis induced by DHR was partially blocked. Thus, we found that DHR induced human plasma cell death by activating the p38 but not the JNK signaling pathway. Because plasma cells are very important in the immune system, this study provided a new insight in the safety evaluation of DHR application.

Natural pesticide dihydrorotenone arrests human plasma cancer cells at the G0/G1 phase of the cell cycle.[Pubmed:24615755]

J Biochem Mol Toxicol. 2014 May;28(5):232-8.

Dihydrorotenone (DHR) is a natural pesticide used for farming including organic produces. We recently found that DHR induces human plasma cell apoptosis by provoking endoplasmic reticulum stress. In the present study, we found that DHR arrested human plasma cancer cells at the G0/G1 phase of the cell cycle. Mechanistical studies demonstrated that cell cycle arrest was associated with downregulated cell cycle promotors including cyclin D2, cyclin D3, cyclin-dependent kinases (CDK4, CKD6), and phosphorylated-Rb. DHR inhibited cyclin D2 transactivation, thus inhibiting its mRNA expression. In addition, DHR upregulated the cell cycle repressors p21 and p53. DHR also increased the phosphorylation level of p53, suggesting the upregulated transactivation function of p53, which was confirmed by the induction of p21, a substrate of activated p53. Moreover, DHR downregulated AKT and ERK phosphorylation, an incentive of cell cycle progression. Therefore, these results collectively demonstrated that DHR disrupts the cell cycle progress, which suggests that DHR is toxic to human plasma cells. Caution is thus suggested when handling with this agent.

Description

Dihydrorotenone, a natural pesticide, is a potent mitochondrial inhibitor. Dihydrorotenone probably induces Parkinsonian syndrome. Dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway.

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