MSOP

CAS# 66515-29-5

MSOP

2D Structure

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3D structure

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MSOP

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Chemical Properties of MSOP

Cas No. 66515-29-5 SDF Download SDF
PubChem ID 3964633 Appearance Powder
Formula C4H10NO6P M.Wt 199.1
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in sterile water
Chemical Name 2-amino-2-methyl-3-phosphonooxypropanoic acid
SMILES CC(COP(=O)(O)O)(C(=O)O)N
Standard InChIKey GSFCOAGADOGIGE-UHFFFAOYSA-N
Standard InChI InChI=1S/C4H10NO6P/c1-4(5,3(6)7)2-11-12(8,9)10/h2,5H2,1H3,(H,6,7)(H2,8,9,10)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of MSOP

DescriptionSelective group III metabotropic glutamate receptor antagonist. Displays an apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Has no activity on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons. Also available as part of the Group III mGlu Receptor Tocriset™.

MSOP Dilution Calculator

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MSOP Molarity Calculator

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Preparing Stock Solutions of MSOP

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.0226 mL 25.113 mL 50.226 mL 100.452 mL 125.565 mL
5 mM 1.0045 mL 5.0226 mL 10.0452 mL 20.0904 mL 25.113 mL
10 mM 0.5023 mL 2.5113 mL 5.0226 mL 10.0452 mL 12.5565 mL
50 mM 0.1005 mL 0.5023 mL 1.0045 mL 2.009 mL 2.5113 mL
100 mM 0.0502 mL 0.2511 mL 0.5023 mL 1.0045 mL 1.2557 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on MSOP

Educating medical students as competent users of health information technologies: the MSOP data.[Pubmed:17911947]

Stud Health Technol Inform. 2007;129(Pt 2):1414-8.

UNLABELLED: As more health information technologies become part of the health care environment, the need for physicians with medical informatics competencies is growing. In 2006, a survey was created to determine the degree to which the Association of American Medical College's Medical School Objectives Project (MSOP) medical informatics competencies had been incorporated into medical school curricula in the United States. METHODS: a web-based tool was used to create the survey; medical education deans or their designees were requested to complete the survey. Analysis focused on the clinician, researcher, and manager roles of physicians. RESULTS: Seventy usable surveys were returned. Many of the objectives were stated in the schools' respective curricula and the competencies were being evaluated. However, only a few schools taught and assessed the medical informatics objectives that required interaction with health information. CONCLUSION: To insure that physicians have the knowledge, skills, and attitudes to effectively and efficiently interact with today's health information technologies, more medical informatics concepts need to be included and assessed in all undergraduate medical education curricula in the United States.

Description

MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR.

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