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Chloranthalactone A

CAS# 66395-02-6

Chloranthalactone A

2D Structure

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Quality Control of Chloranthalactone A

3D structure

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Chloranthalactone A

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Chemical Properties of Chloranthalactone A

Cas No. 66395-02-6 SDF Download SDF
PubChem ID 333361 Appearance Powder
Formula C15H16O2 M.Wt 228.29
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1=C2CC3C(=C)C4CC4C3(C=C2OC1=O)C
Standard InChIKey OVEQSZKTJIUNHZ-JDTTZNEISA-N
Standard InChI InChI=1S/C15H16O2/c1-7-9-4-12(9)15(3)6-13-10(5-11(7)15)8(2)14(16)17-13/h6,9,11-12H,1,4-5H2,2-3H3/t9-,11+,12-,15-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Chloranthalactone A

The roots of Chloranthus serratus.

Biological Activity of Chloranthalactone A

In vitro

Anti-leishmanial lindenane sesquiterpenes from Hedyosmum angustifolium.[Pubmed: 19830657]

Planta Med. 2010 Mar;76(4):365-8.

The aim of this work is the isolation of anti-leishmanial compounds from the ethyl acetate extracts of the bark of HEDYOSMUM ANGUSTIFOLIUM.
METHODS AND RESULTS:
We have successfully isolated and characterized five sesquiterpenes: one new compound (oxyonoseriolide, 1), one compound isolated for the first time from a natural source (hedyosmone, 2), and three known sesquiterpenes (onoseriolide, 3; Chloranthalactone A, 4; and spathulenol, 5) that had not been previously isolated from H. ANGUSTIFOLIUM.
CONCLUSIONS:
The biological activities of 1- 5 showed that onoseriolide ( 3) was the most active compound against axenic amastigotes from LEISHMANIA AMAZONENSIS and L. INFANTUM. Moreover, it was still active on the intramacrophagic amastigotes of L. INFANTUM. The isolated compounds have also been tested on PLASMODIUM FALCIPARUM and against various mammalian cell lines.

Chloranthalactone A Dilution Calculator

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Chloranthalactone A Molarity Calculator

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Preparing Stock Solutions of Chloranthalactone A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.3804 mL 21.902 mL 43.8039 mL 87.6079 mL 109.5098 mL
5 mM 0.8761 mL 4.3804 mL 8.7608 mL 17.5216 mL 21.902 mL
10 mM 0.438 mL 2.1902 mL 4.3804 mL 8.7608 mL 10.951 mL
50 mM 0.0876 mL 0.438 mL 0.8761 mL 1.7522 mL 2.1902 mL
100 mM 0.0438 mL 0.219 mL 0.438 mL 0.8761 mL 1.0951 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Chloranthalactone A

Anti-leishmanial lindenane sesquiterpenes from Hedyosmum angustifolium.[Pubmed:19830657]

Planta Med. 2010 Mar;76(4):365-8.

The aim of this work is the isolation of anti-leishmanial compounds from the ethyl acetate extracts of the bark of HEDYOSMUM ANGUSTIFOLIUM. We have successfully isolated and characterized five sesquiterpenes: one new compound (oxyonoseriolide, 1), one compound isolated for the first time from a natural source (hedyosmone, 2), and three known sesquiterpenes (onoseriolide, 3; Chloranthalactone A, 4; and spathulenol, 5) that had not been previously isolated from H. ANGUSTIFOLIUM. The biological activities of 1- 5 showed that onoseriolide ( 3) was the most active compound against axenic amastigotes from LEISHMANIA AMAZONENSIS and L. INFANTUM. Moreover, it was still active on the intramacrophagic amastigotes of L. INFANTUM. The isolated compounds have also been tested on PLASMODIUM FALCIPARUM and against various mammalian cell lines.

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