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Ranitidine

CAS# 66357-35-5

Ranitidine

Catalog No. BCC9134----Order now to get a substantial discount!

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Quality Control of Ranitidine

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Chemical structure

Ranitidine

3D structure

Chemical Properties of Ranitidine

Cas No. 66357-35-5 SDF Download SDF
PubChem ID 3001055 Appearance Powder
Formula C13H22N4O3S M.Wt 314.4
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (E)-1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine
SMILES CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C
Standard InChIKey VMXUWOKSQNHOCA-UKTHLTGXSA-N
Standard InChI InChI=1S/C13H22N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9,14-15H,6-8,10H2,1-3H3/b13-9+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Ranitidine Dilution Calculator

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Ranitidine Molarity Calculator

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Preparing Stock Solutions of Ranitidine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1807 mL 15.9033 mL 31.8066 mL 63.6132 mL 79.5165 mL
5 mM 0.6361 mL 3.1807 mL 6.3613 mL 12.7226 mL 15.9033 mL
10 mM 0.3181 mL 1.5903 mL 3.1807 mL 6.3613 mL 7.9517 mL
50 mM 0.0636 mL 0.3181 mL 0.6361 mL 1.2723 mL 1.5903 mL
100 mM 0.0318 mL 0.159 mL 0.3181 mL 0.6361 mL 0.7952 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Ranitidine

Ranitidine-induced Thrombocytopenia in a Neonate - A Case Report and Review of Literature.[Pubmed:30837818]

J Pediatr Pharmacol Ther. 2019 Jan-Feb;24(1):66-71.

Thrombocytopenia (platelet count <150 x 10(9)/L) regularly occurs in newborns but is especially observed in critically ill neonates. We describe the case of a small for gestational age (SGA) neonate, who showed an unexpected, severe thrombocytopenia (8 x 10(9)/L) at day 5 of life. The thrombocytopenia recovered completely after cessation of Ranitidine (0.5 mg/kg/6 hr), which was started in a context of feeding difficulties. Other causes of neonatal thrombocytopenia were ruled out. Besides a brief report on a cimetidine-induced thrombocytopenia over 25 years ago, no other neonatal or pediatric cases of H2 antagonist-induced thrombocytopenia have been reported to date, although being widely used in routine care. Moreover, several adult cases have been published. In general, neonatal thrombocytopenia, although one of the most frequent hematological conditions in newborns, is only rarely attributed to an adverse drug reaction. Clinicians should be aware of the risks for adverse reactions, especially in routinely used drugs and in critically ill patients.

Physical Compatibility and Chemical Stability of Injectable and Oral Ranitidine Solutions.[Pubmed:30718932]

Hosp Pharm. 2019 Feb;54(1):32-36.

Objectives: The physical compatibility and chemical stability of Ranitidine hydrochloride injectable solutions and oral syrup were studied to define beyond-use dates (BUDs). Methods: Ranitidine hydrochloride injectable solutions of 25 mg/mL packaged in glass vials and 5 mg/mL in polypropylene (PP) syringes were prepared in triplicate. Samples were refrigerated and protected from light (PFL) or stored at 25 degrees C and either exposed to light (ETL) or PFL. Ranitidine hydrochloride oral syrup 15 mg/mL in unit-dose amber PP syringes were prepared in triplicate and then kept at 25 degrees C. Samples were collected at days 0, 7, 14, 28, 56, and 91. Additional samples were collected at 6 months and at 6, 9, and 12 months for the 25 mg/mL solution and oral syrup, respectively. Physical parameters of pH, clarity, and color were obtained at each collection time. A validated stability-indicating high-performance liquid chromatography (HPLC) method was used to determine the chemical stability. Results: Formulations had no significant change in pH or clarity. Although some samples yellowed, this was not associated with a decrease in concentration. The 25 mg/mL solution remained above 98.6% for 6 months, whereas the 5 mg/mL solution remained above 93.5% for 91 days under all storage conditions. At 25 degrees C, the oral syrup retained greater than 98.8% for 12 months. Conclusions: The Ranitidine hydrochloride injectable solutions were stable for 6 months and 91 days under the 3 storage conditions, respectively, for the 25 mg/mL solution in glass vials and 5 mg/mL solution in PP syringes. The 15 mg/mL oral syrup in unit-dose amber PP syringes was stable for 12 months at 25 degrees C and PFL.

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