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Chloranthalactone B

CAS# 66395-03-7

Chloranthalactone B

Catalog No. BCN8020----Order now to get a substantial discount!

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Quality Control of Chloranthalactone B

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Chemical structure

Chloranthalactone B

3D structure

Chemical Properties of Chloranthalactone B

Cas No. 66395-03-7 SDF Download SDF
PubChem ID 15767607 Appearance Powder
Formula C15H16O3 M.Wt 244.29
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1=C2CC3C(=C)C4CC4C3(C5C2(O5)OC1=O)C
Standard InChIKey ZKAVFYQAEVFXTE-NRLMIDHWSA-N
Standard InChI InChI=1S/C15H16O3/c1-6-8-4-11(8)14(3)9(6)5-10-7(2)12(16)17-15(10)13(14)18-15/h8-9,11,13H,1,4-5H2,2-3H3/t8-,9+,11-,13+,14-,15-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Chloranthalactone B

The roots of Chloranthus serratus

Biological Activity of Chloranthalactone B

Description1. Chloranthalactone B has anti-inflammatory activity, it inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways.
TargetsTNF-α | IL Receptor | TNF-α | COX | NOS | p38MAPK | ERK | JNK | AP-1

Chloranthalactone B Dilution Calculator

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Chloranthalactone B Molarity Calculator

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Preparing Stock Solutions of Chloranthalactone B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.0935 mL 20.4675 mL 40.935 mL 81.8699 mL 102.3374 mL
5 mM 0.8187 mL 4.0935 mL 8.187 mL 16.374 mL 20.4675 mL
10 mM 0.4093 mL 2.0467 mL 4.0935 mL 8.187 mL 10.2337 mL
50 mM 0.0819 mL 0.4093 mL 0.8187 mL 1.6374 mL 2.0467 mL
100 mM 0.0409 mL 0.2047 mL 0.4093 mL 0.8187 mL 1.0234 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Chloranthalactone B

Anti-Inflammatory Effects of Chloranthalactone B in LPS-Stimulated RAW264.7 Cells.[Pubmed:27879664]

Int J Mol Sci. 2016 Nov 22;17(11). pii: ijms17111938.

Chloranthalactone B (CTB), a lindenane-type sesquiterpenoid, was obtained from the Chinese medicinal herb Sarcandra glabra, which is frequently used as a remedy for inflammatory diseases. However, the anti-inflammatory mechanisms of CTB have not been fully elucidated. In this study, we investigated the molecular mechanisms underlying these effects in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. CTB strongly inhibited the production of nitric oxide and pro-inflammatory mediators such as prostaglandin E(2), tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 in RAW264.7 cells stimulated with LPS. A reverse-transcription polymerase chain reaction assay and Western blot further confirmed that CTB inhibited the expression of inducible nitric oxide synthase, cyclooxygenase-2, TNF-alpha, and IL-1beta at the transcriptional level, and decreased the luciferase activities of activator protein (AP)-1 reporter promoters. These data suggest that inhibition occurred at the transcriptional level. In addition, CTB blocked the activation of p38 mitogen-activated protein kinase (MAPK) but not c-Jun N-terminal kinase or extracellular signal-regulated kinase 1/2. Furthermore, CTB suppressed the phosphorylation of MKK3/6 by targeting the binding sites via formation of hydrogen bonds. Our findings clearly show that CTB inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways. Therefore, CTB could potentially be used as an anti-inflammatory agent.

Three novel sesquiterpene glycosides of Sarcandra glabra.[Pubmed:19336941]

Chem Pharm Bull (Tokyo). 2009 Apr;57(4):418-20.

Three new sesquiterpene glycosides, 8 beta,9 beta-epoxy-4 alpha-hydroxy-5 alpha H-lindan-7(11)-en-8 alpha,12-olide-15-O-beta-D-glucopyranoside (1, sarcaglaboside F), 4 alpha-hydroxy-5 alpha,8 beta H-lindan-7(11)-en-8 alpha,12-olide-15-O-beta-D-glucopyranoside (2, sarcaglaboside G), 4 alpha-hydroxy-5 alpha,8 beta H-eudesman-7(11)-en-8 alpha,12-olide-15-O-beta-D-glucopyranoside (3, sarcaglaboside H), together with five known compounds, chloranoside A (4), sarcaglaboside C (5), dihydrovomifoliol-O-beta-D-glucopyranoside (6), 9-hydroxy-heterogorgiolide (7) and Chloranthalactone B (8), were isolated from Sarcandra glabra THUMB. NAKAI. The structures and relative configurations of three new compounds were determined on the basis of their spectroscopic data and chemical evidence.

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