PregomisinCAS# 66280-26-0 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 66280-26-0 | SDF | Download SDF |
| PubChem ID | 181796 | Appearance | Oil |
| Formula | C22H30O6 | M.Wt | 390.47 |
| Type of Compound | Lignans | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5-[(2S,3R)-4-(3-hydroxy-4,5-dimethoxyphenyl)-2,3-dimethylbutyl]-2,3-dimethoxyphenol | ||
| SMILES | CC(CC1=CC(=C(C(=C1)OC)OC)O)C(C)CC2=CC(=C(C(=C2)OC)OC)O | ||
| Standard InChIKey | RLRKIWSBYUZHIJ-OKILXGFUSA-N | ||
| Standard InChI | InChI=1S/C22H30O6/c1-13(7-15-9-17(23)21(27-5)19(11-15)25-3)14(2)8-16-10-18(24)22(28-6)20(12-16)26-4/h9-14,23-24H,7-8H2,1-6H3/t13-,14+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M. |
| Targets | PAFR |
| In vitro | Platelet-activating factor antagonistic activity and(13)C NMR assignment of pregomisin and chamigrenal fromSchisandra chinensis.[Pubmed: 18982271]Arch Pharm Res. 1997 Dec;20(6):633-6.
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| Structure Identification | Chem Pharm Bull (Tokyo). 2007 Aug;55(8):1281-3.Lignans from Schisandra propinqua var. propinqua.[Pubmed: 17666862]
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Pregomisin Dilution Calculator
Pregomisin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.561 mL | 12.8051 mL | 25.6102 mL | 51.2203 mL | 64.0254 mL |
| 5 mM | 0.5122 mL | 2.561 mL | 5.122 mL | 10.2441 mL | 12.8051 mL |
| 10 mM | 0.2561 mL | 1.2805 mL | 2.561 mL | 5.122 mL | 6.4025 mL |
| 50 mM | 0.0512 mL | 0.2561 mL | 0.5122 mL | 1.0244 mL | 1.2805 mL |
| 100 mM | 0.0256 mL | 0.1281 mL | 0.2561 mL | 0.5122 mL | 0.6403 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Lignans from Schisandra propinqua var. propinqua.[Pubmed:17666862]
Chem Pharm Bull (Tokyo). 2007 Aug;55(8):1281-3.
Two new dibenzocyclooctadiene lignans angeloyl-(+)-gomisin K(3) (1) and methylisogomisin O (2), together with six known ones, isogomisin O, angeloylisogomisin O, gomisin O, angeloygomisin O, benzoylgomisin O, epigomisin O, and four 1,4-bis(phenyl)-2,3-dimethylbutane type lignans, Pregomisin, meso-dihydroguaiaretic acid, isoanwulignan, and sphenanlignan were isolated from the aerial parts of Schisandra propinqua var. propinqua. The structures of 1 and 2 were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques.
Platelet-activating factor antagonistic activity and(13)C NMR assignment of pregomisin and chamigrenal fromSchisandra chinensis.[Pubmed:18982271]
Arch Pharm Res. 1997 Dec;20(6):633-6.
In the course of searching for PAF receptor antagonists, Pregomisin (1) and chamigrenal (2) were isolated from the fruits ofSchizandra chinensis Baill by the bioactivity-guided isolation. Both compounds showed PAF antagonistic activity and the IC(50) values were 4.8x10(-5) M and 1.2x10(-4) M, respectively. In addition, the(13)C NMR assignments of1 and2 using DEPT, HMQC, COLOC and HMBC were reported for the first time.
