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4-Amino-2-methylquinoline

CAS# 6628-04-2

4-Amino-2-methylquinoline

Catalog No. BCC8677----Order now to get a substantial discount!

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4-Amino-2-methylquinoline: 5mg $17 In Stock
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Quality Control of 4-Amino-2-methylquinoline

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Chemical structure

4-Amino-2-methylquinoline

3D structure

Chemical Properties of 4-Amino-2-methylquinoline

Cas No. 6628-04-2 SDF Download SDF
PubChem ID 81116 Appearance Powder
Formula C10H10N2 M.Wt 158
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-methylquinolin-4-amine
SMILES CC1=NC2=CC=CC=C2C(=C1)N
Standard InChIKey COCFIBRMFPWUDW-UHFFFAOYSA-N
Standard InChI InChI=1S/C10H10N2/c1-7-6-9(11)8-4-2-3-5-10(8)12-7/h2-6H,1H3,(H2,11,12)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

4-Amino-2-methylquinoline Dilution Calculator

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4-Amino-2-methylquinoline Molarity Calculator

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Preparing Stock Solutions of 4-Amino-2-methylquinoline

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.3291 mL 31.6456 mL 63.2911 mL 126.5823 mL 158.2278 mL
5 mM 1.2658 mL 6.3291 mL 12.6582 mL 25.3165 mL 31.6456 mL
10 mM 0.6329 mL 3.1646 mL 6.3291 mL 12.6582 mL 15.8228 mL
50 mM 0.1266 mL 0.6329 mL 1.2658 mL 2.5316 mL 3.1646 mL
100 mM 0.0633 mL 0.3165 mL 0.6329 mL 1.2658 mL 1.5823 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 4-Amino-2-methylquinoline

Matrix-assisted laser desorption/ionization matrices for negative mode metabolomics.[Pubmed:23841224]

Eur J Mass Spectrom (Chichester). 2013;19(1):39-47.

Matrix-assisted laser desorption/ionization (MALDI) has been shown to be highly sensitive for analyzing low-mass compounds such as metabolites if the right matrix is used. 9-aminoacridine (9AA) is the most commonly employed matrix for negative mode MALDI-MS in metabolomics. However, matrix interferences and the strongly varying sensitivity for different metabolites make a search for alternative matrices desirable, in order to identify compounds with a different chemical background and/or favoring a different range of analytes. We tested the performance of a series of potential negative mode MALDI matrices with a mix of 29 metabolites containing amino acids, nucleotide phosphates and Krebs cycle intermediates. While ethacridine lactate was found to provide limits of detection (LODs) in the low femtomole range for nucleotide phosphates, amino acids and Krebs cycle intermediates in the low picomole range, 4-Amino-2-methylquinoline showed LODs in the picomole range for most metabolites, but is capable of ionizing a broader range of analytes than both 9AA and ethacridine.

Ab initio, density functional theory and structural studies of 4-amino-2-methylquinoline.[Pubmed:19581121]

Spectrochim Acta A Mol Biomol Spectrosc. 2009 Oct 1;74(2):375-84.

The Fourier transform infrared (FTIR) and FT-Raman spectra of 4-Amino-2-methylquinoline (AMQ) have been recorded in the range 4000-400 and 4000-100 cm(-1), respectively. The experimental vibrational frequency was compared with the wavenumbers obtained theoretically by ab initio HF and DFT-B3LYP gradient calculations employing the standard 6-31 G** and high level 6-311 ++G** basis sets for optimised geometry of the compound. The complete vibrational assignment and analysis of the fundamental modes of the compounds were carried out using the experimental FTIR and FT-Raman data, and quantum mechanical studies. The geometry and normal modes of vibration obtained from the HF and DFT methods are in good agreement with the experimental data. The potential energy distribution of the fundamental modes was calculated with ab initio force fields utilising Wilson's FG matrix method. The NH-pi interactions and the influence of amino and methyl groups on the skeletal modes are investigated.

Plasmodium berghei: in vitro and in vivo activity of dequalinium.[Pubmed:16814285]

Exp Parasitol. 2007 Jan;115(1):19-24.

Bisquinoline compounds have exhibited remarkable activity in vitro and in vivo against Plasmodium parasites by inhibition of heme detoxification. We have tested the ability of dequalinium 1,1'-(1,10-decanediyl)bis(4-Amino-2-methylquinoline), a known antimicrobial agent, to inhibit beta-hematin synthesis using a non-emzymatic colorimetric assay and globin proteolysis by electrophoretic analysis (SDS-PAGE-15%). Dequalinium was able to inhibit both processes in vitro with close correlation to a murine malaria model, reducing parasitemia levels, prolonging the survival time post-infection and curing 40% of infected mice using a combination therapy with a loading dose of chloroquine. These results confirm that dequalinium is a promising lead for antimalarial drug development.

A new synthetic approach of N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide (JTC-801) and its analogues and their pharmacological evaluation as nociceptin receptor (NOP) antagonists.[Pubmed:15571866]

Eur J Med Chem. 2004 Dec;39(12):1047-57.

A series of 4-Amino-2-methylquinoline and 4-aminoquinazoline derivatives, including the reference NOP antagonist JTC-801, were synthesized by an alternative pathway and their in vitro pharmacological properties were investigated. 3-Substitution of the quinoline ring resulted very critical for affinity. So 3-methyl derivative 4j showed a similar potency compared with the reference 4h while bulky lipophilic or electron withdrawing groups in the same position strongly decreased affinity. Structural and conformational requirements for affinity were outlined by NOE NMR and computational methods and suggestions for a pharmacophore model design were provided.

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