Propacetamol hydrochlorideCAS# 66532-86-3 |
Quality Control & MSDS
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| Cas No. | 66532-86-3 | SDF | Download SDF |
| PubChem ID | 108082 | Appearance | Powder |
| Formula | C14H21ClN2O3 | M.Wt | 300.8 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (4-acetamidophenyl) 2-(diethylamino)acetate;hydrochloride | ||
| SMILES | CCN(CC)CC(=O)OC1=CC=C(C=C1)NC(=O)C.Cl | ||
| Standard InChIKey | WGTYJNGARJPYKG-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C14H20N2O3.ClH/c1-4-16(5-2)10-14(18)19-13-8-6-12(7-9-13)15-11(3)17;/h6-9H,4-5,10H2,1-3H3,(H,15,17);1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Propacetamol hydrochloride Dilution Calculator
Propacetamol hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3245 mL | 16.6223 mL | 33.2447 mL | 66.4894 mL | 83.1117 mL |
| 5 mM | 0.6649 mL | 3.3245 mL | 6.6489 mL | 13.2979 mL | 16.6223 mL |
| 10 mM | 0.3324 mL | 1.6622 mL | 3.3245 mL | 6.6489 mL | 8.3112 mL |
| 50 mM | 0.0665 mL | 0.3324 mL | 0.6649 mL | 1.3298 mL | 1.6622 mL |
| 100 mM | 0.0332 mL | 0.1662 mL | 0.3324 mL | 0.6649 mL | 0.8311 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Influence of medium and temperature on the hydrolysis kinetics of propacetamol hydrochloride: determination using derivative spectrophotometry.[Pubmed:15744097]
Chem Pharm Bull (Tokyo). 2005 Mar;53(3):277-80.
Propacetamol hydrochloride (PRO) is a water-soluble prodrug of paracetamol (PA) which can be parenterally administered as analgesic for the treatment of postoperative pain, acute trauma, and gastric and/or intestinal disorders where oral administration is not possible. In these circumstances, PRO can be administered in physiologic or glucose solutions since it is rapidly and quantitatively hydrolyzed into PA by plasma estearases. We have studied the degradation kinetics of PRO in 5% glucose and 0.9% saline solutions at 4 degrees C and 25 degrees C (storage and room temperatures, respectively). The analytic technique used to determine PRO and PA quantitatively was first-derivative spectrophotometry. The degradation process of PRO can be best fitted to a second-order kinetics with independence of the medium used (saline or glucose solution). The hydrolysis kinetics of PRO conversion into PA depends on the temperature but not on the assay medium (saline or glucose solution). The degradation rate constants obtained for PRO were approximately 4.5 times higher at 25 degrees C than at 4 degrees C. The values of t(90%) for PRO were 3.17 h and 3.61 h at 25 degrees C, and 13.42 h and 12.36 h at 4 degrees C when the tests were performed in 5% glucose and 0.9% saline solutions, respectively.
