TutinCAS# 2571-22-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 2571-22-4 | SDF | Download SDF |
| PubChem ID | 75729 | Appearance | Powder |
| Formula | C15H18O6 | M.Wt | 294.3 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC(=C)C1C2C(C3(C4(CO4)C5C(C3(C1C(=O)O2)O)O5)C)O | ||
| Standard InChIKey | CCAZWUJBLXKBAY-ULZPOIKGSA-N | ||
| Standard InChI | InChI=1S/C15H18O6/c1-5(2)6-7-12(17)20-8(6)9(16)13(3)14(4-19-14)10-11(21-10)15(7,13)18/h6-11,16,18H,1,4H2,2-3H3/t6-,7+,8+,9+,10+,11-,13-,14+,15-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Tutin in honey, is a plant-derived neurotoxin. |
Tutin Dilution Calculator
Tutin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3979 mL | 16.9895 mL | 33.9789 mL | 67.9579 mL | 84.9473 mL |
| 5 mM | 0.6796 mL | 3.3979 mL | 6.7958 mL | 13.5916 mL | 16.9895 mL |
| 10 mM | 0.3398 mL | 1.6989 mL | 3.3979 mL | 6.7958 mL | 8.4947 mL |
| 50 mM | 0.068 mL | 0.3398 mL | 0.6796 mL | 1.3592 mL | 1.6989 mL |
| 100 mM | 0.034 mL | 0.1699 mL | 0.3398 mL | 0.6796 mL | 0.8495 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Sweet Poisons: Honeys Contaminated with Glycosides of the Neurotoxin Tutin.[Pubmed:25993882]
J Nat Prod. 2015 Jun 26;78(6):1363-9.
Poisonings due to consumption of honeys containing plant toxins have been reported widely. One cause is the neurotoxin Tutin, an oxygenated sesquiterpene picrotoxane, traced back to honeybees (Apis mellifera) collecting honeydew produced by passionvine hoppers (Scolypopa australis) feeding on sap of the poisonous shrub tutu (Coriaria spp.). However, a pharmacokinetic study suggested that unidentified conjugates of Tutin were also present in such honeys. We now report the discovery, using ion trap LC-MS, of two Tutin glycosides and their purification and structure determination as 2-(beta-d-glucopyranosyl)Tutin (4) and 2-[6'-(alpha-d-glucopyranosyl)-beta-d-glucopyranosyl]Tutin (5). These compounds were used to develop a quantitative triple quadrupole LC-MS method for honey analysis, which showed the presence of Tutin (3.6 +/- 0.1 mug/g honey), hyenanchin (19.3 +/- 0.5), Tutin glycoside (4) (4.9 +/- 0.4), and Tutin diglycoside (5) (4.9 +/- 0.1) in one toxic honey. The ratios of 4 and 5 to Tutin varied widely in other Tutin-containing honeys. The glycosidation of Tutin may represent detoxification by one or both of the insects involved in the food chain from plant to honey.
Human pharmacokinetic study of tutin in honey; a plant-derived neurotoxin.[Pubmed:25084484]
Food Chem Toxicol. 2014 Oct;72:234-41.
Over the last 150 years a number of people in New Zealand have been incapacitated, hospitalised, or died from eating honey contaminated with Tutin, a plant-derived neurotoxin. A feature of the most recent poisoning incident in 2008 was the large variability in the onset time of clinical signs and symptoms of toxicity (0.5-17 h). To investigate the basis of this variability a pharmacokinetic study was undertaken in which 6 healthy males received a single oral dose of Tutin-containing honey giving a Tutin dose of 1.8 mug/kg body weight. The serum concentration-time curve for all volunteers exhibited two discrete peaks with the second and higher level occurring at approximately 15 h post-dose. Two subjects reported mild, transient headache at a time post-dose corresponding to maximum Tutin concentrations. There were no other signs or symptoms typical of Tutin intoxication such as nausea, vomiting, dizziness or seizures. Pharmacokinetic analysis using a two-site absorption model resulted in a good fit to the observed concentration data. A novel analytical method subsequently revealed the presence of glycoside conjugates of Tutin in addition to unconjugated Tutin in honey. These pharmacokinetic data will be important to better define a safe maximum Tutin concentration in honey.
