VelutinCAS# 25739-41-7 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 25739-41-7 | SDF | Download SDF |
PubChem ID | 5464381 | Appearance | Yellow powder |
Formula | C17H14O6 | M.Wt | 314.3 |
Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxychromen-4-one | ||
SMILES | COC1=CC(=C2C(=C1)OC(=CC2=O)C3=CC(=C(C=C3)O)OC)O | ||
Standard InChIKey | ROCUOVBWAWAQFD-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C17H14O6/c1-21-10-6-12(19)17-13(20)8-14(23-16(17)7-10)9-3-4-11(18)15(5-9)22-2/h3-8,18-19H,1-2H3 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Velutin has strong anti-inflammatory activity, it can effectively inhibit the expression of proinflammatory cytokines TNF-α and IL-6 in low micromole levels by inhibiting NF-κB activation and p38 and JNK phosphorylation. Velutin controls HIF-1α activity during PgLPS-activated osteoclastogenesis probably through modulation of the NF-κB pathway, perhaps it could be used therapeutically to prevent bone loss seen in periodontitis.Velutin can induce apoptosis in tumor cells. |
Targets | TNF-α | IL Receptor | NF-kB | p38MAPK | JNK | HIF | IkB | IKK |
In vitro | The açaí flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway.[Pubmed: 22137267]J Nutr Biochem. 2012 Sep;23(9):1184-91.Recent studies have shown that some flavonoids are modulators of proinflammatory cytokine production. Differential abilities of the mushroom ribosome-inactivating proteins hypsin and velutin to perturb normal development of cultured mouse embryos.[Pubmed: 20149862]Toxicol In Vitro. 2010 Jun;24(4):1250-7.The teratogenicity of two fungal ribosome-inactivating proteins, hypsin from Hypsizigus mamoreus and Velutin from Flammulina velutipes, was examined in this investigation using microinjection and postimplantation whole-embryo culture. Velutin and betulinic acid isolated from Korean mistletoe induce apoptosis in tumor cells[Reference: WebLink]Yoo Y C, Lee K B. Korea Society of Laboratory Animals, 2003,6: 101-101.Velutin and betulinic acid isolated from Korean mistletoe induce apoptosis in tumor cells. |
Kinase Assay | Velutin reduces lipopolysaccharide-induced proinflammatory cytokine TNFα and IL-6 production by inhibiting NF-κB activation.[Reference: WebLink]Faseb Journal, 2011, 25(1):772.Five flavonoids, (2S,3S)-dihyrokaempferol 3-O-b-D-glucoside (1) and its isomer (2R,3R)-dihydrokaempferol 3-O-b-D-glucoside (2) , isovitexin (3), Velutin (4) and 5,40-dihydroxy-7,30,50-trimethoxyflavone (5), were isolated from acai (Euterpe oleracea Mart.) pulp. |
Cell Research | Velutin Inhibits Osteoclastogenesis by Suppressing HIF-1α and NF-κB pathways.[Reference: WebLink]Aadr Meeting & Exhibition. 2014.Periodontitis is a biofilm-related inflammatory disease that involves progressive loss of alveolar bone around the teeth caused by osteoclasts. While nuclear factor-kappa beta (NF-κB) is involved in periodontal inflammation, another biomolecule, hypoxia-inducible factor 1 alpha (HIF-1α) regulates local tissue hypoxia. Both are likely involved in osteoclastogenesis. Velutin is an anti-inflammatory polyphenol that modulates the NF-κB pathway. The aim of this study was to evaluate the effects of Velutin on osteoclastogenesis in vitrothrough the modulation HIF-1αand NF-κB signaling pathways. |
Velutin Dilution Calculator
Velutin Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 3.1817 mL | 15.9084 mL | 31.8167 mL | 63.6335 mL | 79.5418 mL |
5 mM | 0.6363 mL | 3.1817 mL | 6.3633 mL | 12.7267 mL | 15.9084 mL |
10 mM | 0.3182 mL | 1.5908 mL | 3.1817 mL | 6.3633 mL | 7.9542 mL |
50 mM | 0.0636 mL | 0.3182 mL | 0.6363 mL | 1.2727 mL | 1.5908 mL |
100 mM | 0.0318 mL | 0.1591 mL | 0.3182 mL | 0.6363 mL | 0.7954 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- KF 38789
Catalog No.:BCC5938
CAS No.:257292-29-8
- Homoarbutin
Catalog No.:BCN2680
CAS No.:25712-94-1
- Tutin
Catalog No.:BCN5129
CAS No.:2571-22-4
- Lonicerin
Catalog No.:BCN8266
CAS No.:25694-72-8
- HU 308
Catalog No.:BCC5971
CAS No.:256934-39-1
- Cimiracemoside C
Catalog No.:BCN5128
CAS No.:256925-92-5
- CCK Octapeptide, non-sulfated
Catalog No.:BCC5709
CAS No.:25679-24-7
- 3,2'-Dihydroxy-4,4'-dimethoxychalcone
Catalog No.:BCN7742
CAS No.:2567-65-9
- Cannabigerol
Catalog No.:BCN5127
CAS No.:25654-31-3
- Aponorhyoscine
Catalog No.:BCN1871
CAS No.:25650-56-0
- Nantenine
Catalog No.:BCN7788
CAS No.:2565-01-7
- Dactylorhin A
Catalog No.:BCN8217
CAS No.:256459-34-4
- J 104129 fumarate
Catalog No.:BCC7389
CAS No.:257603-40-0
- CP 154526
Catalog No.:BCC7481
CAS No.:257639-98-8
- H-D-Glu(OBzl)-OH
Catalog No.:BCC2939
CAS No.:2578-33-8
- Pelitinib (EKB-569)
Catalog No.:BCC1118
CAS No.:257933-82-7
- Gemfibrozil
Catalog No.:BCC4783
CAS No.:25812-30-0
- LEP (116-130) (mouse)
Catalog No.:BCC1016
CAS No.:258276-95-8
- Ghrelin (human)
Catalog No.:BCC7076
CAS No.:258279-04-8
- IEM 1925 dihydrobromide
Catalog No.:BCC7885
CAS No.:258282-23-4
- Ghrelin (rat)
Catalog No.:BCC5767
CAS No.:258338-12-4
- H-D-Cys(Trt)-OH
Catalog No.:BCC2914
CAS No.:25840-82-8
- Liensinine
Catalog No.:BCN6337
CAS No.:2586-96-1
- Hoechst 33258 analog
Catalog No.:BCC1624
CAS No.:258843-62-8
The acai flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-alpha and IL-6 production through inhibiting NF-kappaB activation and MAPK pathway.[Pubmed:22137267]
J Nutr Biochem. 2012 Sep;23(9):1184-91.
Recent studies have shown that some flavonoids are modulators of proinflammatory cytokine production. In this study, Velutin, a unique flavone isolated from the pulp of acai fruit (Euterpe oleracea Mart.), was examined for its effects in reducing lipopolysaccharide-induced proinflammatory cytokine tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 production in RAW 264.7 peripheral macrophages and mice peritoneal macrophages. Three other structurally similar and well-studied flavones, luteolin, apigenin and chrysoeriol, were included as controls and for comparative purposes. Velutin exhibited the greatest potency among all flavones in reducing TNF-alpha and IL-6 production. Velutin also showed the strongest inhibitory effect in nuclear factor (NF)-kappaB activation (as assessed by secreted alkaline phosphatase reporter assay) and exhibited the greatest effects in blocking the degradation of inhibitor of NF-kappaB as well as in inhibiting mitogen-activated protein kinase p38 and JNK phosphorylation; all of these are important signaling pathways involved in production of TNF-alpha and IL-6. The present study led to the discovery of a strong anti-inflammatory flavone, Velutin. This compound effectively inhibited the expression of proinflammatory cytokines TNF-alpha and IL-6 in low micromole levels by inhibiting NF-kappaB activation and p38 and JNK phosphorylation.
Differential abilities of the mushroom ribosome-inactivating proteins hypsin and velutin to perturb normal development of cultured mouse embryos.[Pubmed:20149862]
Toxicol In Vitro. 2010 Jun;24(4):1250-7.
The teratogenicity of two fungal ribosome-inactivating proteins, hypsin from Hypsizigus mamoreus and Velutin from Flammulina velutipes, was examined in this investigation using microinjection and postimplantation whole-embryo culture. The results demonstrated that hypsin induced abnormal embryonic development at 2.5 microM during the organogenesis period from E8.5 to E9.5. As its dosage increased, there was an increase in the total number of abnormal embryos, a drop in the final somite number, and a rise of abnormal structures. Structural abnormalities were detected: open cranial neural tube, abnormal branchial arches, absence of forelimb buds and twisted body axis. The otic and optic placodes were, however, less affected. Histological study of the abnormal embryos revealed a correlation of increased cell death with abnormal structures, suggesting that induction of cell death by hypsin may account for its teratogenicity. In contrast, Velutin did not exert any adverse influence on mouse development.